90899-14-2Relevant articles and documents
An alternative and facile synthetic approach for the precursors of 3- and 6-aminosugar donors and study of one-pot glycosyltrasferation
Pandey, Uddav,Prasad Subedi, Yagya,Alfindee, Madher N.,Shepherd, Taylor,Tom Chang, Cheng-Wei
supporting information, p. 99 - 102 (2020/01/03)
3- and 6-aminosugars are common motifs in bioactive compounds playing pivotal roles in the bioactivity of the core molecules to which they are attached. However, de novo synthesis of 3- and 6-aminosugars and their corresponding glycosyl donors can be time
Synthesis of neamine-based pseudodisaccharides as potential vestibulotoxic agents to treat vertigo in Me?nie?re's disease
Pinsetta, Flávio Roberto,Kawano, Daniel Fábio,De Carvalho, Marcelo Rodrigues,De Oliveira, José Ant?nio A.,Corrado, Alexandre P.,Hyppolito, Miguel ?ngelo,Carvalho, Ivone
, p. 97 - 102 (2013/06/27)
Ménière's disease (MD) is a progressive disease of the inner ear characterized by recurring attacks of disabling vertigo, hearing loss and tinnitus. Patients who do not respond to vestibular sedatives or steroids may require an intratympanic application o
Synthesis and biological evaluation of modified 2-deoxystreptamine dimers
Coste, Gerald,Horlacher, Tim,Molina, Lidia,Moreno-Vargas, Antonio J.,Carmona, Ana T.,Robina, Inmaculada,Seeberger, Peter H.,Gerber-Lemaire, Sandrine
, p. 1759 - 1770 (2011/07/30)
Aminoglycosides are powerful antibiotics, but the emergence of resistant bacterial strains has prompted the search for analogues with better pharmacological profiles. The synthesis of 2-deoxystreptamine (2-DOS) dimers linked by polyamines and analogues based on furylcarbopeptoid skeletons is described. Potent and selective ligands for bacterial 16S rRNA were identified using microarray techniques by determining the affinity of these derivatives toward bacterial and human ribosomal RNAs. Georg Thieme Verlag Stuttgart - New York.
An efficient and improved procedure for preparation of triflyl azide and application in catalytic diazotransfer reaction
Yan, Ri-Bai,Yang, Fan,Wu, Yanfen,Zhang, Li-He,Ye, Xin-Shan
, p. 8993 - 8995 (2007/10/03)
An efficient and improved procedure for preparation of triflyl azide and application in catalytic diazotransfer reaction are described. The amount of highly toxic reagents NaN3 and Tf2O, is significantly reduced comparing with the pr
Efficient preparation of a 1,3-diazidocyclitol as a versatile 2-deoxystreptamine precursor
Busscher, Guuske F.,Groothuys, Stan,De Gelder, Rene,Rutjes, Floris P. J. T.,Van Delft, Floris L.
, p. 4477 - 4481 (2007/10/03)
A synthesis route toward 2-deoxystreptamine, a common structure in many of the clinically important aminoglycosides, is presented. Starting from p-benzoquinone and cyclopentadiene, 2-deoxystreptamine is synthesized with key steps involving Pd(0)-catalyzed
Antimicrobial 2-deoxystreptamine compounds
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Page column 19, (2010/02/07)
The present invention is directed to analogs of aminoglycoside compounds of the class having a glycosylated 2-deoxystreptamine (2-DOS) ring as well as their preparation and use as prophylactic or therapeutics against microbial infection. Compounds of the
Synthesis of linked carbohydrates and evaluation of their binding for 16S RNA by mass spectrometry
Wu, Baogen,Yang, Jun,Robinson, Dale,Hofstadler, Steve,Griffey, Rich,Swayze, Eric E.,He, Yun
, p. 3915 - 3918 (2007/10/03)
A library of linked molecules were synthesized from the common sugar moieties existing in the natural amino glycosides. These linked molecules were screened against bacterial 16S RNA for their binding affinity using a mass spectrometry-based technology. Some of these compounds exhibited low micromolar affinity and could serve as leads for further development as antibacterial agents.
Efficient Synthesis of Heterocyclic 2-Deoxysteptamine Derivatives as RNA Binding Ligands
Ding, Yili,Hofstadler, Steven A.,Swayze, Eric E.,Griffey, Richard H.
, p. 908 - 909 (2007/10/03)
An efficient strategy for the synthesis of heterocyclic 2-deoxystreptamine derivatives is described. The resulting compounds showed good RNA binding affinities from ESI-MS RNA binding assay.
The chemistry of amine-azide interconversion: Catalytic diazotransfer and regioselective azide reduction
Nyffeler, Paul T.,Liang, Chang-Hsing,Koeller, Kathryn M.,Wong, Chi-Huey
, p. 10773 - 10778 (2007/10/03)
Azides have proven to be useful precursors to amines in organic syntheses. This report describes an improvement of the diazotransfer reaction and the first example of a regioselective azide reduction of compounds containing multiple azides. The use of a s
Design and synthesis of new aminoglycoside antibiotics containing neamine as an optimal core structure: Correlation of antibiotic activity with in vitro inhibition of translation
Greenberg, William A.,Priestley, E. Scott,Sears, Pamela S.,Alper, Phil B.,Rosenbohm, Christoph,Hendrix, Martin,Hung, Shang-Cheng,Wong, Chi-Huey
, p. 6527 - 6541 (2007/10/03)
The structure and activity of the pseudodisaccharide core found in aminoglycoside antibiotics was probed with a series of synthetic analogues in which the position of amino groups was varied around the glucopyranose ring. The naturally occurring structure
