609347-83-3

Upstream product

• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 609347-79-7 (chloromethyl)dimethyl(2,4-dimethoxyphenyl)silane 
• 17715-69-4 1-Bromo-2,4-dimethoxybenzene 

Downstream Products

• 609347-86-6 2-((2-tert-butoxycarbonylaminoacetyl){[(2,4-dimethoxyphenyl)dimethylsilanyl]methyl}amino)-3-phenylpropionic acid methyl ester 
• 916049-73-5 2-((3-benzyloxy-2-tert-butoxycarbonylaminopropionyl){[(2,4-dimethoxyphenyl)dimethylphenylsilanyl]methyl}amino)-3-phenylpropionic acid methyl ester 
• 609347-87-7 2-(benzyloxycarbonylaminoacetyl-{[(2,4-dimethoxy-phenyl)-dimethyl-silanyl]-methyl}-amino)-3-phenyl-propionic acid 
• 916049-43-9 2-({2-[2-((2-benzyloxycarbonylaminoacetyl){[(2,4-dimethoxyphenyl)dimethylsilanyl]methyl}amino)-3-phenylpropionylamino]acetyl}trimethylsilanylmethylamino)-3-phenylpropionic acid methyl ester 

Relevant academic research and scientific papers

Building functionalized peptidomimetics: Use of electroauxiliaries for introducing N-acyliminium ions into peptides

A series of silyl-substituted amino acids have been synthesized, inserted into peptides, and then employed as precursors for oxidatively generating reactive N-acyliminium ions. Both electrochemical and chemical oxidation procedures have been employed. N-Acyliminium ion generation in a solid-phase substrate as well as application to a small library of functionalized dipeptides has been demonstrated. Limitations in terms of how electron-rich the silyl groups can be as well as the compatibility of multiple silyl groups within a longer peptide are defined.

Building functionalized peptidomimetics: New electroauxiliaries and the use of a chemical oxidant for introducing N-acyliminium ions into peptides

(Matrix presented) The removal of electroauxiliaries from peptide substrates with chemical oxidants has been examined as a method for inserting N-acyliminium ions into the peptides. To this end, it was found that both 4-methoxyphenyldimethylsilyl and 2,4-