609349-33-9Relevant academic research and scientific papers
Anilinopyrazole as selective CDK2 inhibitors: Design, synthesis, biological evaluation, and X-ray crystallographic analysis
Tang, Jun,Shewchuk, Lisa M.,Sato, Hideyuki,Hasegawa, Masaichi,Washio, Yoshiaki,Nishigaki, Naohiko
, p. 2985 - 2988 (2003)
A novel series of anilinopyrazoles has been designed based on the X-ray crystal structure analysis. Most compounds from this series not only show sub-nanomolar IC50 values for CDK2, but also demonstrate almost 1000-fold selectivity to other kinases including CDK1.
