Bioorganic and Medicinal Chemistry Letters p. 2985 - 2988 (2003)
Update date:2022-08-02
Topics:
Tang, Jun
Shewchuk, Lisa M.
Sato, Hideyuki
Hasegawa, Masaichi
Washio, Yoshiaki
Nishigaki, Naohiko
A novel series of anilinopyrazoles has been designed based on the X-ray crystal structure analysis. Most compounds from this series not only show sub-nanomolar IC50 values for CDK2, but also demonstrate almost 1000-fold selectivity to other kinases including CDK1.
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