60940-13-8

Upstream product

• 1234014-76-6 C₇H₃FN₂O₂S 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 76-05-1 trifluoroacetic acid 
• 420111-75-7 1,2-bis(2-fluoro-5-nitrophenyl)disulfane 

Downstream Products

• 60940-14-9 2-fluoro-5-aminotrifluoromethylthio-benzene 
• 20819-71-0 2-Fluor-5-nitro-phenyl-trifluormethylsulfon 

Relevant academic research and scientific papers

HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS

The present invention provides compounds of formula (I) useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf -mediated diseases.

Synthesis of aryl perfluoroalkyl sulfides from aromatic disulfides

Thermolysis of xenon(II) bis(perfluoroalkanecarboxylates) in the presence of diaryl disulfides occurs through the S-S bond cleavage to form dihalo-, halonitro-, and halodinitrophenyl perfluoroalkyl sulfides. The latter type of compounds was obtained for the first time. The main side process is the perfluoroalkylation of the aromatic ring.

Substituted piperazine derivative, its preparation and anorexia compositions containing it

The invention provides a new piperazine derivative, 1-(4-fluoro-3-trifluoromethylthio-phenyl)-piperazine of the formula STR1 and its pharmaceutically acceptable acid addition salts, which is useful as a medicament in human and veterinary therapy because o