60965-08-4

Upstream product

• 5162-44-7 1-bromo-4-butene 
• 120-80-9 benzene-1,2-diol 
• 76670-09-2 Potassium; 2-(4-bromo-butoxy)-phenolate 

Downstream Products

• 696615-35-7 2-(4-hydroxybutyloxy)phenol 
• 696615-44-8 (1S,2R,4S,6R)-2,4-bis(benzyloxy)-6-[4-(2-hydroxyphenyloxy)butyloxy]cyclohexanol 
• 1430847-81-6 1-[[4-[(2-(3-butenyloxy)phenoxy)methyl]-2-(4-chlorophenyl)-1,3-dioxolan-2-yl]methyl]-1H-1,2,4-triazole 

Relevant academic research and scientific papers

Removal of the phosphate group in mechanism-based inhibitors of inositol monophosphatase leads to unusual inhibitory activity.

Inositol monophosphatase is widely held to be the therapeutic target for inhibition by lithium ion in the treatment of bipolar disorder. In a continued effort to improve the bioavailability of alternative inhibitors, we have designed and tested two new se

Ring-Closure Reactions. 21. Intramolecular β-Elimination Competing with Ring Formation from o-(ω-Bromoalkoxy)phenoxides over a Wide Range of Ring Sizes

Unimolecular β-elimination of HBr from the CH2CH2Br end of o--OC6H4O(CH2)n-4Br has been interpreted as an E2-type reaction promoted by the distal phenoxide group acting as a base.Combination of careful product analyses with kinetic data has provided rate constants and effective molarities for intramolecularly assisted elimination reactions occurring through 7-, 8-, 9-, 10-, and 14-membered ring transition states.A comparison is carried out with the competing intramolecular substitution reactions leading to ring formation.Attention is called to the specific entropic and geometrical requirements of intramolecular elimination in which the donor-proton-acceptor arrangement is a part of a cyclic structure.The importance of the present results in the general field of intramolecular acid or base catalysis phenomena is discussed.