60965-24-4

Basic information

• Product Name: 2-bromo-1-(2-hydroxy-4-methoxyphenyl)ethanone
• Synonyms: 2-bromo-1-(2-hydroxy-4-methoxyphenyl)ethanone
• CAS NO: 60965-24-4
• Molecular Formula: C₉H₉BrO₃
• Molecular Weight: 245.06996
• Mol File: 60965-24-4.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-bromo-1-(2-hydroxy-4-methoxyphenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-1-(2-hydroxy-4-methoxyphenyl)ethanone(60965-24-4)
• EPA Substance Registry System: 2-bromo-1-(2-hydroxy-4-methoxyphenyl)ethanone(60965-24-4)

Safety Data

• Hazardous Substances Data: 60965-24-4(Hazardous Substances Data)

Upstream product

• 598-21-0 2-Bromoacetyl bromide 
• 151-10-0 1,3-Dimethoxybenzene 
• 150-19-6 O-methylresorcine 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 

Downstream Products

• 91515-96-7 1-(2-Hydroxy-4-methoxy-phenyl)-2-imidazol-1-yl-ethanone 
• 55960-07-1 2,2'-dihydroxy-4'-methoxyacetophenone 
• 1381777-49-6 2-(imidazo[1,2-a]pyridin-2-yl)-5-methoxyphenol 
• 1403876-02-7 1-(2-hydroxy-4-methoxyphenyl)-2-[4-(4-methylphenyl)-1H-1,2,3-triazol-1-yl]ethan-1-one 
• 1403876-00-5 2-[4-(4-ethylphenyl)-1H-1,2,3-triazol-1-yl]-1-(2-hydroxy-4-methoxyphenyl)ethan-1-one 
• 1403875-99-9 1-(2-hydroxy-4-methoxyphenyl)-2-[4-(4-propylphenyl)-1H-1,2,3-triazol-1-yl]ethan-1-one 
• 1403875-98-8 2-(4-cyclopropyl-1H-1,2,3-triazol-1-yl)-1-(2-hydroxy-4-methoxyphenyl)-ethan-1-one 
• 1403875-97-7 1-(2-hydroxy-4-methoxyphenyl)-2-{4-[(3-metylphenoxy)methyl]-1H-1,2,3-triazol-1-yl}ethan-1-one 
• 1403875-96-6 1-(2-hydroxy-4-methoxyphenyl)-2-{4-[(4-chlorophenoxy)methyl]-1H-1,2,3-triazol-1-yl}ethan-1-one 
• 1315362-38-9 2-azido-1-(2-hydroxy-4-methoxyphenyl)ethanone 

Relevant articles and documents

A Palladium-Catalyzed Oxa-(4+4)-Cycloaddition Strategy towards Oxazocine Scaffolds

A Pd-catalyzed oxa-(4+4)-cycloaddition between 1-azadienes and (2-hydroxymethyl)allyl carbonates is described. Aurone-derived azadienes furnished polycyclic 1,5-oxazocines in good yields. Interestingly, linear azadienes have also been involved and yielded monocyclic heterocycles with complete regioselectivity. DFT calculations were carried out to gain insight on this observation.

Nucleus-independent chemical shift (NICS) as a criterion for the design of new antifungal benzofuranones

The assertion made by Wu et al. that aromaticity may have considerable implications for molecular design motivated us to use nucleus-independent chemical shifts (NICS) as an aromaticity criterion to evaluate the antifungal activity of two series of indol-4-ones. A linear regression analysis of NICS and antifungal activity showed that both tested variables were significantly related (p –1 for Candida glabrata, Candida krusei and Candida guilliermondii with compounds 15-32, 15-15 and 15-1. The MIC for filamentous fungi was 1.95 μg·mL–1 for Aspergillus niger for compounds 15-1, 15-33 and 15-34. The results obtained support the use of NICS in the molecular design of compounds with antifungal activity.

PdCl2/CuCl2/Bi(OTf)3-promoted Construction of Sulfonyl Dibenzooxabicyclo[3.3.1]nonanes and Arylnaphthalenes via Intramolecular Annulation of Sulfonyl o-Allylarylchromanones

PdCl2/CuCl2/Bi(OTf)3-promoted intramolecular domino annulation of sulfonyl o-allylarylchromanones provides tetracyclic sulfonyl dibenzooxabicyclo[3.3.1]nonanes and bicyclic arylnaphthalenes with good to excellent yields in MeOH at room (25 °C) and refluxing (65 °C) temperature, respectively. The starting sulfonyl o-allylarylchromanones can be easily obtained from the intermolecular cyclocondensation of α-sulfonyl o-hydroxyacetophenones and o-allylbenzaldehydes. The uses of various catalysts and solvent systems are investigated herein for convenient transformation. A plausible mechanism is proposed and discussed. This protocol provides one-pot ring closure via carbon-carbon (C?C) bond formation. (Figure presented.).