91515-96-7Relevant academic research and scientific papers
2-Hydroxyphenacyl azoles and related azolium derivatives as antifungal agents
Emami, Saeed,Foroumadi, Alireza,Falahati, Mehraban,Lotfali, Ensieh,Rajabalian, Saeed,Ebrahimi, Soltan-Ahmed,Farahyar, Shirin,Shafiee, Abbas
, p. 141 - 146 (2008/09/17)
2-Hydroxyphenacyl azole and 2-hydroxyphenacyl azolium compounds have been described as a new class of azole antifungals. Most target compounds showed significant in vitro antifungal activities against tested fungi (Candida albicans, Saccharomyces cerevisiae, Aspergillus niger, and Microsporum gypseum) with low MICs values included in the range of 0.25-32 μg/mL comparable to reference drug fluconazole. The most active compounds were also assessed for their cytotoxicity using MTT colorimetric assay on normal mouse fibroblast (NIH/3T3) cells. The results of antifungal activity and toxicity tests indicated that these compounds display antifungal activity at non-cytotoxic concentrations.
N-Imidazolylchroman-4-ones, N-imidazolyl-1-tetralones, and their alcohols as hypolipemic agents raising high-density lipoproteins
Cozzi,Branzoli,Lovisolo,Orsini,Carganico,Pillan,Chiari
, p. 404 - 410 (2007/10/02)
A series of 3-(1-imidazolyl)chroman-4-ones and 2-(1-imidazolyl)-1-tetralones II, some of their alcohols, and some related compounds were synthesized and tested for hypolipidemic activity. Compounds II, bearing appropriate lipophilic substituents on the phenyl ring, strongly reduced total serum cholesterol while raising high-density lipoprotein cholesterol in diet-induced hypercholesterolemic rats. 3-(1-Imidazolyl)chroman-4-ols and 2-(1-imidazolyl)-1-tetralols corresponding to II retained the hypolipidemic activity while removal of the carbonyl or hydroxy group adjacent to imidazole gave inactive compounds. Although many of the active compounds significantly increased liver weight, the one studied as a model, 6-chloro-3-(1-imidazolyl)-2,3-dihydro-4H-1-benzopyran-4-one (5), caused no peroxisome proliferation. Compound 5 and the corresponding alcohol, as representatives of the ketone and alcohol series, showed significant hypolipidemic activity in normolipemic rats. Some of the compounds assayed in cholesterol biosynthesis inhibited acetate incorporation but none inhibited HMG-CoA reductase. 5-Bromo-6-hydroxy-2-(1-imidazolyl)-3,4-dihydro-1(2H)-naphthalenon e, which showed strong activity but caused little hepatomegaly in the rat, was chosen for further pharmacological evaluation.
Imidazolyl Derivatives of The Chroman Ring. 1.
Cozzi, Paolo,Mongelli, Nicola,Pillan, Antonio
, p. 311 - 315 (2007/10/02)
The synthesis of 2-(1H-imidazol-1-yl)-2,3-dihydro-2H-1-benzopyran-4-ones (I) through 3-bromo-2,3-dihydro-4H-1-benzopyran-4-ones or more conveniently through chroman ring closure from 2-(1H-imidazol-1-yl)-2'-hydroxy-acetophenones is described.The ring closure also works well for the pyrazolyl derivatives.Compounds I and the corresponding imidazolylchromanols, -chromenes, and -chromans derived from the former, were pharmacologically investigated.
