60965-25-5

Usage

Preparation

Preparation by reaction of acetic acid on 4-bromoresorcinol with zinc chloride (Nencki reaction).

Upstream product

• 6626-15-9 4-Bromoresorcinol 
• 64-19-7 acetic acid 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 42059-48-3 acetic acid 4-acetyl-3-hydroxyphenyl ester 

Downstream Products

• 78050-57-4 (E)-1-(5-Bromo-2,4-dihydroxy-phenyl)-3-(2-hydroxy-phenyl)-propenone 
• 78050-53-0 (E)-1-(5-Bromo-2,4-dihydroxy-phenyl)-3-(3,4-dimethoxy-phenyl)-propenone 
• 118024-32-1 1-Phenyl-5-(2,4-dihydroxy-5-bromphenyl)-1,3-pentadiene-5-one 
• 2896-60-8 4-ethyl-1,3-benzenediol 
• 38493-24-2 6-bromo-7-hydroxy-2-(4-methoxy-phenyl)-chromen-4-one 
• 78050-72-3 7-Hydroxy-6-bromo-2-phenyl-1H-chromene-4-one 
• 78050-75-6 6-Bromo-7-hydroxy-2-(4-hydroxy-phenyl)-chromen-4-one 
• 78050-74-5 6-Bromo-7-hydroxy-2-(3-hydroxy-4-methoxy-phenyl)-chromen-4-one 
• 78050-73-4 6-Bromo-2-(3,4-dimethoxy-phenyl)-7-hydroxy-chromen-4-one 
• 78050-76-7 5-(6-Bromo-7-hydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxy-benzoic acid 
• 1484-73-7 6-Ethyl-7-hydroxy-4-methylcumarin 
• 212694-37-6 6-bromo-7-hydroxy-4-methyl-3-phenyl-coumarin 
• 99969-44-5 4-ethyl-6-chloro-resorcinol 
• 78050-56-3 5-[(E)-3-(5-Bromo-2,4-dihydroxy-phenyl)-3-oxo-propenyl]-2-hydroxy-benzoic acid 

Relevant academic research and scientific papers

o-xylylene bis(triethyl ammonium tribromide) as a mild and recyclable reagent for rapid and regioselective bromination of anilines and phenols

Background: o-Xylylene bis(triethyl ammonium tribromide) (OXBTEATB) as a recyclable and high bromine containing di-(tribromide) reagent has been employed for the bromination of various organic substrates such as phenol and aniline or its derivatives. This catalyst can be recovered and reused several times. Methods: Aryl bromides shown in Table 1, were easily produced from bromination of aromatic compounds by OXBTEATB. This high-yield process lets the reagents to be recycled and reused. Results: As shown in Table 1, substituted anilines, phenols and β-naphthol were found to be the most reactive and immediately converted to the corresponding mono-brominated products by OXBTEATB. Conclusion: OXBTEATB can be considered a solidified bromine. This novel reagent has variable solubility in different polar protic and aprotic solvents but insoluble in non-polar aprotic solvent. Subsequently, OXBTEATB can be recognized as a more useful brominating and regioselective catalyst than the liquid bromine.

The heck reaction of protected hydroxychromones: On route to natural products

The Heck reaction has been successfully extended to the bromochromones with an adjacent protected phenolic hydroxy group which offers a new methodology to various naturally occurring derivatives including tricyclic O-heterocycles. Phosphine-free coupling conditions are found to be effective. Surprisingly, the methoxymethyl protecting group is unstable in several cases but benzyl proved to be an ideal protecting group which could be selectively cleaved by boron trihalides in good yields. CSIRO 2011.

Fibrinogen receptor antagonists and their use

This invention relates to novel fused bicyclic compounds of the general formula (I): wherein the symbols are defined herein, to pharmaceutical compositions containing the compounds, processes for preparing the compounds, and to methods of using the compounds, alone or in combination with other therapeutic agents. The compounds are antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, and are therefore useful for the inhibition of platelet aggregation, and for the treatment of thrombotic diseases and other diseases.

An efficient, rapid and regioselective nuclear bromination of aromatics and heteroaromatics with NBS using sulfonic-acid-functionalized silica as a heterogeneous recyclable catalyst

A simple, efficient and rapid method has been developed for high-yielding regioselective nuclear monobromination of aromatic and heteroaromatic compounds using NBS in the presence of sulfonic-acid-functionalized silica at room temperature. The catalyst works under heterogeneous conditions and can be recycled.

FIBRINOGEN RECEPTOR ANTAGONISTS AND THEIR USE

This invention relates to novel fused bicyclic compounds of the general formula (I): wherein the symbols are defined herein, to pharmaceutical compositions containing the compounds, processes for preparing the compounds, and to methods of using the compounds, alone or in combination with other therapeutic agents. The compounds are antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, and are therefore useful for the inhibition of platelet aggregation, and for the treatment of thrombotic diseases and other diseases.