609770-35-6

Usage

Uses

Used in Organic Synthesis:
2-(azidomethyl)pyridine(SALTDATA: FREE) is used as a precursor in organic synthesis for the creation of a variety of organic compounds. Its azido group enables the formation of new carbon-carbon or carbon-nitrogen bonds through reactions such as azide-alkyne cycloaddition, making it a valuable component in the synthesis of complex organic molecules.
Used in Medicinal Chemistry and Pharmaceutical Research:
In the field of medicinal chemistry and pharmaceutical research, 2-(azidomethyl)pyridine(SALTDATA: FREE) is utilized as a building block for the development of potential drug candidates. Its unique structure and reactivity contribute to the design and synthesis of novel compounds with therapeutic potential.
Used in Chemical Research:
2-(azidomethyl)pyridine(SALTDATA: FREE) is employed in chemical research to explore the properties and reactions of azide-containing compounds. This helps in understanding the broader implications and applications of azide chemistry in various chemical processes and reactions.

Upstream product

• 4377-33-7 2-chloromethylpyridine 

Downstream Products

• 1224434-24-5 2-(4-methoxyphenyl)-N-((1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methyl)diazenecarboxamide 
• 1224434-25-6 2-(4-fluorophenyl)-N-((1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methyl)diazenecarboxamide 
• 1224434-26-7 2-(4-nitrophenyl)-N-((1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methyl)diazenecarboxamide 
• 1224434-20-1 2-phenyl-N-((1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methyl)diazenecarboxamide 
• 1224434-21-2 N-((1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methyl)-2-p-tolyldiazenecarboxamide 
• 1224434-22-3 2-(4-chlorophenyl)-N-((1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methyl)diazenecarboxamide 
• 1224434-23-4 N-((1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methyl)-2-(4-(trifluoromethyl)phenyl)diazenecarboxamide 
• 1192206-01-1 2-{[4-phenyl-1H-1,2,3-triazol-1-yl]methyl}pyridine 
• 1227780-04-2 1-tert-butyl-3-(6-(3,5-dimethoxyphenyl)-2-((1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methylamino)pyrido[2,3-d]pyrimidin-7-yl)urea 
• 1227780-11-1 1-tert-butyl-3-(6-(3,5-dimethoxyphenyl)-2-(3-(1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl)propylamino)pyrido[2,3-d]pyrimidin-7-yl)urea 
• 1227780-12-2 1-tert-butyl-3-(6-(3,5-dimethoxyphenyl)-2-(4-(1-((pyridine-2-yl-methyl)methyl)-1H-1,2,3-triazol-4-yl)butylamino)pyrido[2,3-d]pyrimidin-7-yl)urea 
• 100-70-9 2-Cyanopyridine 
• 1246847-68-6 2-[(4-(4-methoxyphenyl)-1H-1,2,3-triazol-1-yl)methyl]pyridine 
• 1207756-53-3 C₆H₄(C₂HN₃CH₂C₅H₄N)2 

Relevant academic research and scientific papers

Synthesis, characterization and low temperature self assembling of (η3-allyl)palladium complexes with 2-pyridyl-1,2,3-triazole bidentate ligands. Study of the catalytic activity in Suzuki-Miyaura reaction

The cationic complexes [Pd(η3-C3H 5)(2-((4-propyl-1H-1,2,3-triazol-1-yl)methyl)pyridine)](X) (2: X = BF4-, 3: X = ClO4-), and [Pd(η3-2-CH3-C3Hsu

Synthesis of 1,2,3-triazole derivatives of hydnocarpic acid isolated from carpotroche brasiliensis seed oil and evaluation of antiproliferative activity

Carpotroche brasiliensis is a tree native to Brazil, belonging to the family Flacurtiaceae, whose seeds contain a group of cyclopentenyl fatty acids: Gorlic (12%), chaulmugric (27%), and hydnocarpic (48.7%). These compounds are considered the main therapeutic agents in the treatment of leprosy. In the present study, a series of novel triazole compounds were obtained by conjugation between hydnocarpic acid and functionalized azides via copper(I)-catalyzed azidealkyne cycloaddition reaction (CuAAC). Hydnocarpic acid and its derivatives were tested against estrogen-positive breast carcinoma (MCF-7), hepatocellular carcinoma (HepG2), and non-small cell lung cancer (A549) cell lines. The (R)-(1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methyl-11-(cyclopent-2-en-1-yl)undecanoate (8) displayed promising antiproliferative activity against A549 cells. We demonstrated that this compound selectively inhibited the viability of A549 cell cultures. Furthermore, compound 8 inhibited the clonogenic capacity of A549 cells, and this effect was associated to its ability to inhibit cell cycle progression at G1 phase. These findings indicate that 8 is a promising antitumor agent on A549 cells and support further studies to evaluate the molecular mechanisms underlying its antiproliferative activity. In addition, hydnocarpic acid should be considered as a promising chemical prototype to obtain novel antineoplastic agents.

Pyridine-phosphinimine ligand-accelerated Cu(I)-catalyzed azide-alkyne cycloaddition for preparation of 1-(pyridin-2-yl)-1,2,3-triazole derivatives

A series of phosphinimine ligands were designed and used in the Cu(i)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction of tetrazolo[1,5-a]pyridines and alkynes for the first time. By optimizing the reaction conditions, an efficient catalytic system (CuCl/2-PyCH 2NPtBu3) was developed to give 1-(pyridin-2-yl)-1,2,3-triazole derivatives in moderate to excellent yields (46-98%). This journal is the Partner Organisations 2014.

Synthesis and biological evaluation of a triazole-based library of pyrido[2,3-d]pyrimidines as FGFR3 tyrosine kinase inhibitors

A library of pyrido[2,3-d]pyrimidines was designed as inhibitors of FGFR3 tyrosine kinase allowing possible interactions with an unexploited region of the ATP binding-site. This library was built-up with an efficient step of click-chemistry giving easy access to triazole-based compounds bearing a large panel of substituents. Among the 27 analogues synthesized, more than half exhibited 55-89% inhibition of in vitro FGFR3 kinase activity at 2 μM and one (19g) was able to inhibit auto-phosphorylation of mutant FGFR3-K650M in transfected HEK cells.

Synthesis of click-chelator via Cu(I)-catalyzed alkyne-azide cycloaddition

The click-ligands based on 1,2,3-triazole and pyridine unit has been synthesized via Cu(I)-catalyzed alkyne-azide cycloaddition from corresponding organic azides and terminal alkynes. The ligand structure was characterized by NMR, IR and elemental analysis as well as single crystal diffractions. The single crystal structure of the complexes from two different ligands coordinating to Cu(II) and Co(II) ions indicated that the N(2) atom in 1,2,3-triazole unit can act as an efficient donor to metals through the rational molecular design. Copyright