609771-69-9Relevant academic research and scientific papers
Enantioselective Formal Synthesis of the Cytotoxic Topoisomerase II Inhibitor Deoxythysanone, Catalyzed by Chiral Spiroborate Ester
Chopade, A. U.,Chopade, M. U.,Nikalje, M. D.,Patil, H. S.
, p. 693 - 697 (2020/06/01)
Abstract: Bioactive pyranonaphthoquinone analogs, (1R,3S)-deoxythysanone,(1R,3S)-thysanone, and (1R,3S)-demethoxythysanone can be efficientlysynthesized from a common intermediate product, (S)-3-methyl-3,4-dihydro-1H-isochromene-5,8-dione. We have develop
Organocatalytic approach to (s)-1-arylpropan-2-ols: Enantioselective synthesis of the key intermediate of antiepileptic agent (-)-talampanel
Sawant, Rajiv T.,Waghmode, Suresh B.
experimental part, p. 2269 - 2277 (2010/09/11)
An efficient organocatalytic route for the preparation of enantioselective synthesis of (S)-1-arylpropan-2-ols derivatives, including the key intermediate of antiepileptic agent (-)-talampanel is described. The key steps involved are L-proline-catalyzed a
Stereospecific synthesis of amphetamines
Wagner, Jared M.,McElhinny Jr., Charles J.,Lewin, Anita H.,Carroll, F. Ivy
, p. 2119 - 2125 (2007/10/03)
Regioselective addition of aryl lithium to commercially available (S)-(+)-propylene oxide provides the corresponding (S)-aryl-2-propanol. The (R)-amphetamine is obtained by conversion of the alcohol to the tosylate followed by azide displacement and hydrogenation. Mitsunobu conversion of the alcohol to the (R)-bromide followed by azide displacement and hydrogenation affords the (S)-amphetamine.
