609771-70-2

Upstream product

• 25245-34-5 1-bromo-2,5-dimethoxybenzene 
• 98-59-9 p-toluenesulfonyl chloride 
• 609771-69-9 (2S)-1-(2,5-dimethoxyphenyl)-2-propanol 

Downstream Products

• 58993-81-0 (-)-DMA 
• 609771-72-4 (2R)-1-(2,5-dimethoxyphenyl)-2-propyl azide 

Relevant academic research and scientific papers

Stereospecific synthesis of amphetamines

Regioselective addition of aryl lithium to commercially available (S)-(+)-propylene oxide provides the corresponding (S)-aryl-2-propanol. The (R)-amphetamine is obtained by conversion of the alcohol to the tosylate followed by azide displacement and hydrogenation. Mitsunobu conversion of the alcohol to the (R)-bromide followed by azide displacement and hydrogenation affords the (S)-amphetamine.