609844-13-5Relevant academic research and scientific papers
Synthesis and biological evaluation of 14-alkoxymorphinans. 20.1 14-Phenylpropoxymetopon: An extremely powerful analgesic
Schütz, Johannes,Spetea, Mariana,Hoch, Martin,Aceto, Mario D.,Harris, Louis S.,Coop, Andrew,Schmidhammer, Helmut
, p. 4182 - 4187 (2003)
The synthesis and the biological and pharmacological evaluation of several 14-phenylpropoxy analogues of 14-methoxymetopon are described. Most of the new compounds were nonselective and exhibited binding affinities in the subnanomolar or low nanomolar ran
MORPHINAN DERIVATIVES THE QUATERNARY AMMONIUM SALTS THEREOF SUBSTITUTED IN POSITION 14, METHOD FOR PRODUCTION AND USE THEREOF
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Page/Page column 45-46, (2010/02/06)
The invention relates to a class of morphinan compounds and the quaternary ammonium salts thereof, substituted in position 14, which may be used as highly-active analgesics or also as opioid antagonists. The invention further relates to the pharmaceutically-acceptable salts and easily-produced derivatives thereof, a process for production thereof and use thereof in the production of pharmaceutical specialities.
