609844-26-0

Upstream product

• 609844-14-6 4,5α-epoxy-3-methoxy-5β,17-dimethyl-14β-[(3-phenylpropyl)oxy]morphinan-6-one 
• 609844-13-5 7,8-didehydro-4,5α-epoxy-3-methoxy-5β,17-dimethyl-14β-{[(E)-3-phenylprop-2-enyl]oxy}morphinan-6-one 
• 4392-24-9 3-bromo-1-phenyl-1-propenyl bromide 
• 121720-01-2 14β-hydroxy-5β-methylcodeinone 
• 77-78-1 dimethyl sulfate 
• 609844-24-8 4-hydroxy-3-methoxy-5β,17-dimethyl-14β-[(3-phenylpropyl)oxy]morphinan-6-one 

Relevant academic research and scientific papers

MORPHINAN DERIVATIVES THE QUATERNARY AMMONIUM SALTS THEREOF SUBSTITUTED IN POSITION 14, METHOD FOR PRODUCTION AND USE THEREOF

The invention relates to a class of morphinan compounds and the quaternary ammonium salts thereof, substituted in position 14, which may be used as highly-active analgesics or also as opioid antagonists. The invention further relates to the pharmaceutically-acceptable salts and easily-produced derivatives thereof, a process for production thereof and use thereof in the production of pharmaceutical specialities.

Synthesis and biological evaluation of 14-alkoxymorphinans. 20.1 14-Phenylpropoxymetopon: An extremely powerful analgesic

The synthesis and the biological and pharmacological evaluation of several 14-phenylpropoxy analogues of 14-methoxymetopon are described. Most of the new compounds were nonselective and exhibited binding affinities in the subnanomolar or low nanomolar ran