609848-44-4

Basic information

• Product Name: METHYL 5-(3-IODOPHENYL)ISOXAZOLE-3-CARBOXYLATE
• Synonyms: METHYL 5-(3-IODOPHENYL)ISOXAZOLE-3-CARBOXYLATE;5-(3-iodo-phenyl)-isoxazole-3-carboxylic acid methyl ester
• CAS NO: 609848-44-4
• Molecular Formula: C₁₁H₈INO₃
• Molecular Weight: 329.09
• Mol File: 609848-44-4.mol

Chemical Properties

• Boiling Point: 447.0±40.0 °C(Predicted)
• Appearance: /
• Density: 1.725±0.06 g/cm3(Predicted)
• PKA: -6.55±0.38(Predicted)
• CAS DataBase Reference: METHYL 5-(3-IODOPHENYL)ISOXAZOLE-3-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 5-(3-IODOPHENYL)ISOXAZOLE-3-CARBOXYLATE(609848-44-4)
• EPA Substance Registry System: METHYL 5-(3-IODOPHENYL)ISOXAZOLE-3-CARBOXYLATE(609848-44-4)

Safety Data

• Hazardous Substances Data: 609848-44-4(Hazardous Substances Data)

Upstream product

• 956267-47-3 4-(3-Iodo-phenyl)-2,4-dioxo-butyric acid methyl ester 
• 553-90-2 Dimethyl oxalate 
• 14452-30-3 3'-iodoacetophenone 

Downstream Products

• 369382-23-0 [5-(3-Iodophenyl)isoxazol-3-yl]methanol 
• 745079-06-5 methyl 5-(3-((1E)-4-((tert-butyl(dimethyl)silyl)oxy)-3-(3-hydroxy-2-(methoxycarbonyl)phenoxy)but-1-enyl)phenyl)isoxazole-3-carboxylate 
• 745078-95-9 Methyl 5-(3'-(3-(methoxycarbonyl)isoxazol-5-yl)-1,1'-biphenyl-3-yl)isoxazole-3-carboxylate 
• 956360-06-8 Methyl 5-(3-cyanophenyl)isoxazole-3-carboxylate 

Relevant articles and documents

Substituted piperazines as metabotropic glutamate receptor antagonists

The invention relates to compounds of formula I or pharmaceutically acceptable salts or solvates thereof: where Ar1, Ar2, Hy, L, R1, m and n are as defined in the description. The invention also includes pharmaceutical compositions and uses thereof, processes for making the compounds, as well as methods for the medical treatment of mGluR5-mediated disorders.

MGluR5 modulators VI

The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.

MGluR5 modulators V

The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.

Protein-tyrosine phosphatase inhibitors and uses thereof

The present invention is directed to compounds of formula (I), or a pharmaceutically suitable salt or prodrug thereof, which are useful for the selective inhibition of protein tyrosine phosphatase-1B (PTP1B), and are useful for the treatment of disorders caused by overexpressed or altered protein tyrosine phosphatase 1B.

Fragment screening and assembly: A highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor

Using an NMR-based fragment screening and X-ray crystal structure-based assembly, starting with millimolar ligands for both the catalytic site and the second phosphotyrosine binding site, we have identified a small-molecule inhibitor of protein tyrosine phosphatase 1B with low micromolar inhibition constant, high selectivity (30-fold) over the highly homologous T-cell protein tyrosine phosphatase, and good cellular activity in COS-7 cells.