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609850-40-0

C22H22F5NO2 is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 609850-40-0 Structure

  • Basic information

    1. Product Name: C22H22F5NO2
    2. Synonyms:
    3. CAS NO:609850-40-0
    4. Molecular Formula:
    5. Molecular Weight: 427.414
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 609850-40-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: C22H22F5NO2(CAS DataBase Reference)
    10. NIST Chemistry Reference: C22H22F5NO2(609850-40-0)
    11. EPA Substance Registry System: C22H22F5NO2(609850-40-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 609850-40-0(Hazardous Substances Data)

609850-40-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 609850-40-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,0,9,8,5 and 0 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 609850-40:
(8*6)+(7*0)+(6*9)+(5*8)+(4*5)+(3*0)+(2*4)+(1*0)=170
170 % 10 = 0
So 609850-40-0 is a valid CAS Registry Number.

609850-40-0Downstream Products

609850-40-0Relevant articles and documents

Non-steroidal dissociated glucocorticoid agonists: Indoles as A-ring mimetics and function-regulating pharmacophores

Betageri, Raj,Gilmore, Thomas,Kuzmich, Daniel,Kirrane, Thomas M.,Bentzien, J?rg,Wiedenmayer, Dieter,Bekkali, Younes,Regan, John,Berry, Angela,Latli, Bachir,Kukulka, Alison J.,Fadra, Tazmeen N.,Nelson, Richard M.,Goldrick, Susan,Zuvela-Jelaska, Ljiljana,Souza, Don,Pelletier, Josephine,Dinallo, Roger,Panzenbeck, Mark,Torcellini, Carol,Lee, Heewon,Pack, Edward,Harcken, Christian,Nabozny, Gerald,Thomson, David S.

, p. 6842 - 6851 (2011/12/22)

We report a SAR of non-steroidal glucocorticoid mimetics that utilize indoles as A-ring mimetics. Detailed SAR is discussed with a focus on improving PR and MR selectivity, GR agonism, and in vitro dissociation profile. SAR analysis led to compound (R)-33 which showed high PR and MR selectivity, potent agonist activity, and reduced transactivation activity in the MMTV and aromatase assays. The compound is equipotent to prednisolone in the LPS-TNF model of inflammation. In mouse CIA, at 30 mg/kg compound (R)-33 inhibited disease progression with an efficacy similar to the 3 mg/kg dose of prednisolone.

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