60986-84-7

Upstream product

• 64748-71-6 N-methyl-5-(4-methylphenacyl)-3-phenyl-4-isoxazole carboxamide 
• 60986-70-1 5-(2-hydroxy-2-p-tolyl-ethyl)-3-phenyl-isoxazole-4-carboxylic acid methylamide 
• 60986-88-1 N,5-dimethyl-3-phenyl-isoxazole-4-carboxamide 

Downstream Products

• 64748-72-7 6-(4-bromomethyl-phenyl)-5-methyl-3-phenyl-5H-isoxazolo[4,5-c]pyridin-4-one 
• 64769-68-2 BVT₀₀₂₆₅₉C 

Relevant academic research and scientific papers

METHODS OF USING SUBSTITUTED ISOXAZOLO PYRIDINONES AS DISSOCIATED GLUCOCORTICOIDS

A method for treating a subject having an inflammatory or auto-immune disease with a substituted isoxazolo pyridinone. Also, a method for administering a substituted isoxazolo pyridinone to a cell to retain or increase glucocorticoid receptor transrepression activity with only minimal glucocorticoid receptor transactivation activity.

[...] , etc.

The invention provides compounds of formula I, wherein X, Y, R1, R2, and R3 are as defined in the description, and the preparation thereof. The compounds of formula I are useful as pharmaceuticals.

Substituted isoxazolo pyridinones

This disclosure describes novel compounds of the formula STR1 where R1 is straight chain lower alkyl, and R2 and R3 independently represent hydrogen or lower alkyl or together with N represent STR2 where X is CH2, O or N--CH3, and R4 is hydrogen, halo having an atomic weight of about 19 to 36 or lower alkoxy Which are useful as hypolipidemic agents.