64769-68-2

Usage

Chemical structure

It contains a phenyl group connected to a dimethylaminomethyl group, a methyl group, and an oxa-4,8-diazabicyclo[4.3.0]nona-2,7,10-trien-5-one core structure.

Potential pharmaceutical or biological activities

The chemical structure suggests potential applications in pharmaceutical or biological fields, but further research and analysis would be needed to understand its properties fully.

InChI:InChI=1/C22H21N3O2/c1-24(2)14-15-9-11-16(12-10-15)18-13-19-20(22(26)25(18)3)21(23-27-19)17-7-5-4-6-8-17/h4-13H,14H2,1-3H3

Upstream product

• 64748-72-7 6-(4-bromomethyl-phenyl)-5-methyl-3-phenyl-5H-isoxazolo[4,5-c]pyridin-4-one 
• 64748-71-6 N-methyl-5-(4-methylphenacyl)-3-phenyl-4-isoxazole carboxamide 
• 60986-70-1 5-(2-hydroxy-2-p-tolyl-ethyl)-3-phenyl-isoxazole-4-carboxylic acid methylamide 
• 60986-84-7 5-methyl-3-phenyl-6-(p-tolyl)-isoxazolo[4,5-c]pyridin-4(5H)-one 
• 16883-16-2 5-methyl-3-phenylisoxazole-4-carbonyl chloride 
• 1136-45-4 5-methyl-3-phenylisoxazol-4-carboxylic acid 
• 945761-31-9 4-dimethylaminomethyl-N-methoxy-N-methyl-benzamide 
• 60986-88-1 N,5-dimethyl-3-phenyl-isoxazole-4-carboxamide 
• 18364-71-1 4-((dimethylamino)methyl)benzoic acid 

Relevant academic research and scientific papers

METHODS OF USING SUBSTITUTED ISOXAZOLO PYRIDINONES AS DISSOCIATED GLUCOCORTICOIDS

A method for treating a subject having an inflammatory or auto-immune disease with a substituted isoxazolo pyridinone. Also, a method for administering a substituted isoxazolo pyridinone to a cell to retain or increase glucocorticoid receptor transrepression activity with only minimal glucocorticoid receptor transactivation activity.

Identification of a series of highly potent activators of the Nurr1 signaling pathway

The nuclear receptor Nurr1 (NR4A2) is critically involved in the development and maintenance of midbrain dopaminergic neurons and is believed to function independently of endogenous activation. The hit identification and SAR studies leading to isoxazolo-pyridinone 7e, a highly potent, brain penetrable activator of the Nurr1 signaling pathway, are described.

Substituted isoxazolo pyridinones

This disclosure describes novel compounds of the formula STR1 where R1 is straight chain lower alkyl, and R2 and R3 independently represent hydrogen or lower alkyl or together with N represent STR2 where X is CH2, O or N--CH3, and R4 is hydrogen, halo having an atomic weight of about 19 to 36 or lower alkoxy Which are useful as hypolipidemic agents.