60987-60-2Relevant academic research and scientific papers
New 9- or 10-arylpiperazinoalkyl substituted pyrimido- or diazepino[2,1- f]purines with partial or full 5-HT(1A) agonistic activity
Pawlowski, MacIej,Katlabi, Jacek,Drabczynska, Anna,Duszynska, Beata,Charakchieva-Minol, Sijka,Deren-Wesolek, Anna,Tatarczynska, Ewa,Chojnacka-Wojcik, Ewa,Mokrosz, Maria J.,Bojarski, Andrzej J.
, p. 167 - 175 (1999)
5HT(1A) and 5HT(2A) receptor affinities of several γ-(3'-chloro- or 2'- methoxyphenyl)-piperazinopropyl derivatives of pyrimido [2,1-f]purines or 1,3-diazepino[2,1-f]purines are reported. Some behavioral models demonstrated that 1,3-dimethyl-9-{3-[4-(2'-methoxyphenyl)1-piperazinyl]propyl}-2,4- dioxo-1,3,6,7,8,9-hexahydropyrimido[2,1-f]purine 5b and 1,3-dimethyl-9-{3- [4-(2'-methoxyphenyl)-1-piperazinyl]propyl}-2,4,8-trioxo-1,3-dihydro-9H- pyrimido[2,1-f]purine 8b, may be classified as partial agonist and a full agonist, respectively of pre- and post-synaptic 5HT(1A) receptors.
