60999-59-9Relevant academic research and scientific papers
NEW DATA ON DERIVATIVES OF 1-ALKOXYAZIRIDINE-2-CARBOXYLIC ACIDS
Prosyanik, A.V.,Bondarenko, S.V.,Markov, V.I.,Chervin, I.I.,Isobaev, M.D.,et al.
, p. 154 - 158 (1980)
Esters of β-alkoxyamino-α-bromopropionic acids were obtained by reaction of α,β-dibromopropionic acid esters with alkoxyamines in the presence of triethylamine at 20 deg C for 1 month.When the products are refluxed in acetonitrile in the presence of triethylamine, they are converted to aziridines.Selective amidation of the alkoxyaziridines with excess dimethylamine in absolute methanol in the presence of sodium methoxide leads to enrichment with the cis isomer.The parameters of inversion of the nitrogen atom in the alkoxyaziridines were determined.
N-Substituted aziridine-2-carboxylic acid immunostimulant derivatives
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, (2008/06/13)
The present invention provides pharmaceutical compositions containing N-substituted aziridine-2-carboxylic acid derivatives of the general formula: STR1 wherein X is a carboxyl, a cyano, an alkoxycarbonyl or an optionally substituted carbamoyl radical, R is a hydrogen atom, or an optionally substituted aliphatic hydrocarbon radical or cycloalkyl or cycloalkenyl radical, and R1 is a hydrogen atom or an alkyl or phenyl radical; and the pharmacologically acceptable salts thereof, in admixture with a pharmaceutical diluent or carrier. The present invention also provides, as new compounds, N-substituted aziridine-2-carboxylic acid derivatives of general formula (I') but with the proviso that when X is a carbamoyl or alkoxycarbonyl radical and R1 is a hydrogen atom, R is not a methyl, ethyl, isopropyl or benzyl radical; and the pharmacologically acceptable salts thereof, and also provides processes for the preparation of these new compounds. Furthermore, the present invention is concerned with the use of the compounds of general formula (I') and of the pharmacologically acceptable salts thereof for combating diseases associated with a weakening of the immune system.
