61-56-3

Usage

Uses

Used in Pharmaceutical Industry:
Sultiame is used as an anticonvulsant for the treatment of benign and symptomatic focal epilepsy. It helps in managing seizures by inhibiting the enzyme carbonic anhydrase, which plays a role in the development of epileptic seizures.
Brand Names:
Sultiame is available under the brand names Conadil (3M Pharmaceuticals) and Trolone (3M Pharmaceuticals), making it accessible to patients in need of anticonvulsant medication.

InChI:InChI=1/C10H14N2O4S2/c11-18(15,16)10-5-3-9(4-6-10)12-7-1-2-8-17(12,13)14/h3-6H,1-2,7-8H2,(H2,11,15,16)

Upstream product

• 1633-84-7 4-chloro-1-butanesulfonyl chloride 
• 63-74-1 sulfanilamide 

Relevant academic research and scientific papers

Enantioselective Hydroamination of Alkenes with Sulfonamides Enabled by Proton-Coupled Electron Transfer

An enantioselective, radical-based method for the intramolecular hydroamination of alkenes with sulfonamides is reported. These reactions are proposed to proceed via N-centered radicals formed by proton-coupled electron transfer (PCET) activation of sulfonamide N-H bonds. Noncovalent interactions between the neutral sulfonamidyl radical and a chiral phosphoric acid generated in the PCET event are hypothesized to serve as the basis for asymmetric induction in a subsequent C-N bond forming step, achieving selectivities of up to 98:2 er. These results offer further support for the ability of noncovalent interactions to enforce stereoselectivity in reactions of transient and highly reactive open-shell intermediates.