61-57-4 Usage
Pharmacology
Niridazole exhibits schistosomicide and amebicidal action. The mechanism of action is not
known. It seems likely that it is concentrated in the parasite organism, which causes inhibition of phosphorylase activation, which is expressed in the depletion of glycogen reserves.It also may inhibit spermatogenesis of parasites by affecting the production of eggs. It is
used for diseases caused by Dracunculus meddinesis, as well as Shistosoma haematobium
and Shistosoma mansoni. It belongs to a group of tertiary drugs and is used only in the
absence of the drug of choice. Synonyms of this drug are ambilhar and others.
Safety Profile
Confirmed carcinogen with experimental carcinogenic and neoplastigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Experimental reproductive effects. Human mutation data reported. Used as an amoebicide and schistosomicidal agent.
Synthesis
Niridazole, 1-(5-nitro-2-thiazolyl)-2-imidazolidinone (38.1.11), is made by
reacting 2-amino-5-nitrothiazol with 2-chloroethylisocyanate to make the disubstituted
urea (38.1.10). Heating this compound results in an intramolecular N-alkylation reaction
to form the desired imidazolidine derivative, niridazole.
Check Digit Verification of cas no
The CAS Registry Mumber 61-57-4 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 1 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 61-57:
(4*6)+(3*1)+(2*5)+(1*7)=44
44 % 10 = 4
So 61-57-4 is a valid CAS Registry Number.
InChI:InChI=1/C3H2N2O2S/c6-5(7)3-4-1-2-8-3/h1-2H
