61-81-4

Basic information

• Product Name: Cyclopropanamine,2-phenyl-, hydrochloride (1:1)
• Synonyms: Cyclopropanamine,2-phenyl-, hydrochloride (9CI); Cyclopropylamine, 2-phenyl-, hydrochloride(8CI); 2-Phenylcyclopropylamine hydrochloride; NSC 156919
• CAS NO: 61-81-4
• Molecular Formula: C₉H₁₁N*ClH
• Molecular Weight: 169.65
• Mol File: 61-81-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 218.3 °C at 760 mmHg
• Flash Point: 90.8 °C
• CAS DataBase Reference: Cyclopropanamine,2-phenyl-, hydrochloride (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropanamine,2-phenyl-, hydrochloride (1:1)(61-81-4)
• EPA Substance Registry System: Cyclopropanamine,2-phenyl-, hydrochloride (1:1)(61-81-4)

Safety Data

• Hazardous Substances Data: 61-81-4(Hazardous Substances Data)

Usage

General Description

Cyclopropanamine,2-phenyl-, hydrochloride (1:1) is a chemical compound that consists of a cyclopropane ring attached to an amine group and a phenyl group, with a hydrochloride salt attached. It is used in the synthesis of various pharmaceuticals and organic compounds. Cyclopropanamine,2-phenyl-, hydrochloride (1:1) is known to have biological and pharmacological effects, and its properties make it a valuable building block for the creation of new drugs and research compounds. However, it should be handled with care and in accordance with proper safety protocols due to its potentially hazardous nature.

Upstream product

• 847644-86-4 C₁₄H₁₉NO₂ 
• 847644-86-4 ((1SR,2RS)-tert-butyl-2-phenylcyclopropyl)carbamate 
• 103-26-4 Methyl cinnamate 
• 5861-31-4 methyl trans-2-phenylcyclopropanecarboxylate 
• 939-90-2 trans-2-phenylcyclopropane-1-carboxylic acid 

Downstream Products

• 1986-47-6 tranylcypromine hydrochloride 
• 128413-75-2 N-Adamantan-1-yl-N'-((1R,2R)-2-phenyl-cyclopropyl)-guanidine 
• 133941-07-8 (+/-)-N-trans-(2-phenylcyclopropyl)bromoacetamide 

Relevant articles and documents

Diastereoselective Photoredox-Catalyzed [3 + 2] Cycloadditions of N-Sulfonyl Cyclopropylamines with Electron-Deficient Olefins

A highly diastereoselective, visible-light-induced [3 + 2] cycloaddition between N-sulfonyl cyclopropylamines and electron-deficient olefins is reported. The reactions proceed via the oxidation of a sulfonamide aza-anion by an organic photocatalyst to generate a nitrogen-centered radical. Strain-induced ring opening and intermolecular addition to the olefin generate an intermediate carbon-centered radical that is reduced to an anion prior to 5-exo cyclization. This enables a highly diastereoselective construction of trans-cyclopentanes possessing synthetically useful functional groups.

C-H activation enables a rapid structure-activity relationship study of arylcyclopropyl amines for potent and selective LSD1 inhibitors

We describe the structure-activity relationship of various arylcyclopropylamines (ACPAs), which are potent LSD1 inhibitors. More than 45 ACPAs were synthesized rapidly by an unconventional method that we have recently developed, consisting of a C-H borylation and cross-coupling sequence starting from cyclopropylamine. We also generated NCD38 derivatives, which are known as LSD1 selective inhibitors, and discovered a more effective inhibitor compared to the original NCD38.

(HETERO)ARYL CYCLOPROPYLAMINE COMPOUNDS AS LSD1 INHIBITORS

The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula (I) as described and defined herein, and their use in therapy, including, e.g., in the treatment or prevention of cancer, a neurological disease or condition, or a viral infection.