61014-91-3

Basic information

• Product Name: ETHYL 4-(1-METHYLETHYL)PIPERAZINE-1-CARBOXYLATE
• Synonyms: ETHYL 4-(1-METHYLETHYL)PIPERAZINE-1-CARBOXYLATE;Ethyl 4-isopropylpiperazine-1-carboxylate, 98%
• CAS NO: 61014-91-3
• Molecular Formula: C₁₀H₂₀N₂O₂
• Molecular Weight: 200.28
• Mol File: 61014-91-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 128-130°C 14mm
• Flash Point: 128-130°C/14mm
• Appearance: /
• Density: 1.028g/cm³
• Vapor Pressure: 0.0113mmHg at 25°C
• Refractive Index: 1.4680
• CAS DataBase Reference: ETHYL 4-(1-METHYLETHYL)PIPERAZINE-1-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-(1-METHYLETHYL)PIPERAZINE-1-CARBOXYLATE(61014-91-3)
• EPA Substance Registry System: ETHYL 4-(1-METHYLETHYL)PIPERAZINE-1-CARBOXYLATE(61014-91-3)

Safety Data

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 61014-91-3(Hazardous Substances Data)

Usage

General Description

Ethyl 4-(1-methylethyl)piperazine-1-carboxylate is a chemical compound that belongs to the class of piperazine derivatives. It is a clear, colorless liquid with a molecular formula of C10H20N2O2 and a molecular weight of 200.28 g/mol. ETHYL 4-(1-METHYLETHYL)PIPERAZINE-1-CARBOXYLATE is often used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also known to have potential therapeutic properties, including as an anticancer agent and as a central nervous system depressant. Ethyl 4-(1-methylethyl)piperazine-1-carboxylate is considered to be a relatively stable and non-reactive compound under normal conditions, with low volatility and solubility in water.

InChI:InChI=1/C10H20N2O2/c1-4-14-10(13)12-7-5-11(6-8-12)9(2)3/h9H,4-8H2,1-3H3

Upstream product

• 120-43-4 4-ethoxycarbonylpiperazine 
• 75-30-9 2-iodo-propane 

Downstream Products

• 4489-53-6 2-<4-(1-methylethyl)piperazin-1-yl>ethylamine 
• 240143-46-8 (4-isopropyl-piperazin-1-yl)-acetonitrile 
• 4318-42-7 1-(1-methylethyl)piperazine 

Relevant articles and documents

Novel water-soluble sedative-hypnotic agents: Isoindolin-1-one derivatives

We developed new intravenous sedative-hypnotic compounds with the isoindolin-1-one skeleton focusing on the water-soluble property and in vivo safety. We synthesized approximately 170 derivatives and evaluated their hypnotic effects by intravenous administration of the compounds to mice. A series of the 2-phenyl-3-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]isoindolin-1-one analogs, 3(-), 5(-), 27(-), and 47(-) [JM-1232(-)], showed potent sedative-hypnotic activity with good water solubility and a wide safety margin. The hypnotic doses (HD50s) of these 4 compounds when administered to mice were 2.35, 1.90, 2.17, and 3.12 mg/kg, respectively, and the lethal doses (LD50s) were 88.67, 64.69, >120, and >120 mg/kg, respectively. The therapeutic indexes (LD50/HD50) were 37.73, 34.05, >55.30, and >38.46, respectively. Among these compound, 47(-) [JM-1232(-)] is being considered as the most potential candidate for clinical trials in humans.

Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof

This invention relates to tri- and tetra-substituted-oxetanes, e.g. (±)-cis- and (±)-trans-2-[(4-(4-isopropylpiperazin-1-yl)phenoxy)methyl]-4-(2,4-dihalophenyl)-4-[1H-1,2,4-triazol-1-yl)-methyl]oxetane and tri- and tetra-substituted-tetrahydrofurans, e.g. (±)-cis- and (±)-trans-1-[4-[[2-(2,4-dihalophenyl)tetrahydro-2-[(1H-azol-1-yl)methyl]-5-furanylmethoxy]phenyl]-4-yl-1-substituted piperazine-3-one and related derivatives which exhibit antifungal and antiallergy activities, pharmaceutical composition thereof, methods of their use in treating or preventing susceptible fungal infections and allergic reactions in a host including warm-blooded animals such as humans.