61023-86-7Relevant academic research and scientific papers
Synthesis and anticonvulsant activity of some cinnamylpiperazine derivatives
Hu, Chuan,Sun, Zhi-Gang,Wei, Cheng-Xi,Quan, Zhe-Shan
scheme or table, p. 661 - 664 (2011/11/29)
A series of cinnamylpiperazine derivatives was synthesized using different benzophenone as starting material. The structures of the compounds were proved by their IR, 1H-NMR spectroscopic data and mass spectra data. The anticonvulsant activities of these compounds were evaluated with maximal electroshock (MES) test and rotarod test with intraperitoneal injection on KunMing mice. Among all the flunarizine analogues, no one exhibited better anticonvulsant activity than flunarizine. Flunarizine (4i) exhibited anticonvulsant activity with ED50 of 38.1 mg/kg, TD50 of 164.3 mg/kg and PI of 4.3 through administration intraperitoneal, and with ED50 of 56.8 mg/kg, TD50 of 456.3 mg/kg and PI of 8.0 through oral administration.
Process for the preparation of substituted arylcyanoalkyl and diaryl cyanoalkylimidazoles
-
, (2008/06/13)
This invention relates to a process for the preparation of substituted arylcyanoalkyl and diarylcyanoalkylimidazoles, their acid addition salts and their metal salt complexes. These compounds are useful as broad spectrum protectant-eradicant fungicides.
Substituted arylcyanoalkyl and diarylcyanoalkylimidazoles and fungical compositions and methods utilizing them
-
, (2008/06/13)
This invention relates to substituted arylcyanoalkyl and diarylcyanoalkylimidazoles, their acid addition salts and their metal salt complexes and their use as broad spectrum protectant-eradicant fungicides.
