85-29-0

Basic information

• Product Name: 2,4'-Dichlorobenzophenone
• Synonyms: LABOTEST-BB LT00455493;(2-chlorophenyl)-(4-chlorophenyl)methanone;2,4'-DCBP;2,4'-DICHLOROBENZOPHENONE;(2-chlorophenyl)(4-chlorophenyl)-methanon;Benzophenone, 2,4'-dichloro-;benzophenone,2,4’-dichloro-;dichlorobenzophenone
• CAS NO: 85-29-0
• Molecular Formula: C₁₃H₈Cl₂O
• Molecular Weight: 251.11
• EINECS: 201-596-7
• Product Categories: FINE Chemical & INTERMEDIATES;Aromatic Benzophenones & Derivatives (substituted);Benzophenones (for High-Performance Polymer Research);Functional Materials;Reagent for High-Performance Polymer Research
• Mol File: 85-29-0.mol
• Article Data: 18

Chemical Properties

• Melting Point: 64°C
• Boiling Point: 214 °C / 22mmHg
• Flash Point: 155.2 °C
• Appearance: White crystal powder
• Density: 1.3930
• Refractive Index: 1.5555 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Soluble), Methanol (Slightly)
• BRN: 1959090
• CAS DataBase Reference: 2,4'-Dichlorobenzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4'-Dichlorobenzophenone(85-29-0)
• EPA Substance Registry System: 2,4'-Dichlorobenzophenone(85-29-0)

Safety Data

• Statements: 36/37/38-38-37-36
• Safety Statements: 26-36/37/39-37
• TSCA: Yes
• Hazardous Substances Data: 85-29-0(Hazardous Substances Data)

Usage

Chemical Properties

Whitecrystal powder

Uses

2,4''-Dichlorobenzophenone is used in the synthesis of triarylcarbinol analogs of fenarimol as potent inhibitors of Trypanosoma cruzi. It can also be used to prepare fatty acid amide hydrolase inhibitors.

Upstream product

• 7446-70-0 aluminium trichloride 
• 108-90-7 chlorobenzene 
• 74-11-3 para-chlorobenzoic acid 
• 56-23-5 tetrachloromethane 
• 637-87-6 1-Chloro-4-iodobenzene 
• 67-66-3 chloroform 
• 3900-89-8 2-Chlorobenzeneboronic acid 
• 1679-18-1 4-Chlorophenylboronic acid 
• 75-98-9 Trimethylacetic acid 
• 104-88-1 4-chlorobenzaldehyde 
• 118-91-2 ortho-chlorobenzoic acid 
• 609-65-4 o-chlorobenzoyl chloride 
• 488149-34-4 2-chloro-N-methoxy-N-methyl-pyridine-3-carboxamide 
• 873-77-8 (4-chlorphenyl)magnesium bromide 

Downstream Products

• 101875-98-3 (2-chlorophenyl)(4-chlorophenyl)pyridin-2-yl methanol 
• 62715-63-3 3-(2-chloro-phenyl)-3-(4-chloro-phenyl)-2-cyano-acrylic acid ethyl ester 
• 39274-24-3 1-o-Chlorophenyl-1-p'-chlorophenylethylene 
• 146470-10-2 C₁₄H₁₂Cl₂N₄*ClH 
• 146470-36-2 C₂₀H₁₆Cl₂N₄*HNO₃ 
• 34877-75-3 2-(2-Chlor-phenyl)-2-(4-chlor-phenyl)-acetaldehyd 
• 52094-02-7 o-Chlorophenyl-1-p'-chlorophenylmethane 
• 77008-62-9 1-(o-chlorophenyl)-1-(p-chlorophenyl)ethane 
• 90284-72-3 1,2-Dichloro-2-o-chlorophenyl-2-p'-chlorophenylethane 
• 93694-04-3 (2-chloro-phenyl)-bis-(4-chloro-phenyl)-methane 
• 861532-79-8 (2-chloro-phenyl)-bis-(4-chloro-phenyl)-methanol 
• 1039166-03-4 (RS)-N-[(2-Chlorophenyl)(4-chlorophenyl)methyl]-2-oxo-2-(1'H,3H-spiro[2-benzofuran-1,4'-piperidin]-1'-yl)ethanamine 
• 1241941-39-8 1-(2-chlorophenyl)-1-(4-chlorophenyl)-2-[3-(trifluoromethyl)phenyl]ethanol 
• 791118-68-8 1-benzhydryl-3-[(2-chlorophenyl)-(4-chlorophenyl)-methoxy]-azetidine 

Relevant articles and documents

Asymmetric Transfer Hydrogenation of Diaryl Ketones with Ethanol Catalyzed by Chiral NCP Pincer Iridium Complexes

The use of a chiral (NCP)Ir complex as the precatalyst allowed for the discovery of asymmetric transfer hydrogenation of diaryl ketones with ethanol as the hydrogen source and solvent. This reaction was applicable to various ortho-substituted diaryl keontes, affording benzhydrols in good yields and enantioselectivities. This protocol could be carried out in a gram scale under mild reaction conditions. The utility of the catalytic system was highlighted by the synthesis of the key precursor of (S)-neobenodine.

Pd-Catalyzed Suzuki–Miyaura Cross-Coupling of Arylboronic Acids and α-Iminonitriles through C–CN Bond Activation

A Pd-catalyzed Suzuki–Miyaura cross-coupling reaction between arylboronic acids and α-iminonitriles has been developed. The reaction proceeds through selective activation of the C–CN bond, tolerates a wide range of substituents, and delivers the versatile ketone products in moderate to excellent yields.

Chloro-ruthenium complexes with carbonyl and N-(aryl)pyridine-2-aldimines as ancillary ligands. Synthesis, characterization and catalytic application in C-C cross-coupling of arylaldehydes with arylboronic acids

Reaction of N-(aryl)pyridine-2-aldimines (L-R, R = OCH3, CH 3, H, Cl and NO2) with [Ru(CO)2Cl 2]n in refluxing ethanol affords a group of complexes of type [Ru(L-R)(CO)2Cl2]. In these complexes the diimine ligands (L-R) are coordinated to the metal center as NN-donors forming five-membered chelate rings, the carbonyls are mutually cis and the two chlorides are trans. Crystal structure of [Ru(L-OCH3)(CO) 2Cl2] has been determined. All the complexes show characteristic 1H NMR signals, and in dichloromethane solution they display intense absorptions in the visible and ultraviolet regions. Cyclic voltammetry on the complexes shows an irreversible oxidation of the metal center within 1.15-1.23 V vs SCE, and reduction(s) of the diimine ligand within -0.70 to -0.96 V vs SCE. The [Ru(L-R)(CO)2Cl2] complexes efficiently catalyze cross-coupling of arylaldehydes with arylboronic acids yielding diaryl ketones.