610296-41-8

Upstream product

• 908249-10-5 N-benzyloxycarbonyl-1-(2-methylphenyl)-1,2,3,4-tetrahydroisoquinoline 
• 610298-61-8 1-(2'-methylphenyl)-3,4-dihydroisoquinoline 
• 346689-66-5 2-methyl-N-phenethylbenzamide 
• 933-88-0 ortho-toluoyl chloride 
• 64-04-0 phenethylamine 
• 142266-67-9 N-benzyloxycarbonyl-1,2,3,4-tetrahydroisoquinoline 
• 14099-81-1 1,2,3,4-tetrahydroisoquinoline 

Downstream Products

• 1426226-98-3 2-(S)-(1-o-tolyl-3,4-dihydro-1H-isoquinolin-2-yl)-propionic acid tert-butyl ester 
• 610296-40-7 (S)-1-(o-tolyl)-1,2,3,4-tetrahydroisoquinoline 
• 610296-32-7 N-(indan-2-yl)-N-(2-fluorobenzyl)-2-[(1S)-1-(2-methylphenyl)-3,4-dihydroisoquinolin-2(1H)-yl]acetamide 
• 610296-33-8 N-(2-fluoro-benzyl)-N-indan-2-yl-2-(S)-[1-(S)-o-tolyl-3,4-dihydro-1H-isoquinolin-2-yl]-propionamide 
• 610298-54-9 2-(S)-[1-(S)-o-tolyl-3,4-dihydro-1H-isoquinolin-2-yl]-propionic acid 
• 610298-52-7 2-(S)-[1-(R)-o-tolyl-3,4-dihydro-1H-isoquinolin-2-yl]-propionic acid 

Relevant academic research and scientific papers

SMALL MOLECULE ANTIVIRAL DRUG TREATMENT FOR HUMAN PAPILLOMAVIRUS INFECTIONS

Compositions and methods are provided for treating HPV infections including pre-malignant and cancers. Compounds that specifically bind to the HPV E6 protein and inactivate the protein are disclose.

Affinity of?1-aryl-1,2,3,4-tetrahydroisoquinoline derivatives to?the?ion channel binding site of?the?NMDA receptor complex

A series of 1-aryl-1,2,3,4-tetrahydroisoquinoline and 8-methyl-1-aryl-1,2,3,4-tetrahydroisoquinoline derivatives was evaluated for affinity to the PCP binding site of the NMDA receptor complex. The (S)-configurated tetrahydroisoquinoline derivative (S)-4e·HCl bearing a 2-methylphenyl substituent in position 1 of the heterocyclic ring system and a methyl group in position 8 was found to exhibit the highest affinity among the derivatives with a Ki-value of 0.0374?μM. In addition, this compound shows a remarkable enantioselectivity of binding by being almost 90 times more potent than the corresponding (R)-enantiomer (R)-4e·HCl. Additionally, a convenient and efficient synthetic approach to racemic 1-aryl-1,2,3,4-tetrahydroisoquinoline derivatives is described.