610312-05-5Relevant academic research and scientific papers
Introduction of a carbohydrate moiety into the structure of thiourea compounds targeting HIV-1 reverse transcriptase
Goud, P. Mallikarjun,Venkatachalam,Uckun
, p. 1185 - 1193 (2003)
We developed a novel approach to introduce a carbohydrate moiety into the structure of thiourea compounds targeting the NNI binding pocket of the HIV-1 reverse transcriptase. The described method involves the synthesis of an amino-substituted carbohydrate moiety which is then condensed with various thiocarbonylimidazole derivatives of substituted aromatic amines.
