610313-92-3Relevant articles and documents
A concise and stereoselective synthesis of squalamine
Zhang, Dong-Hui,Cai, Feng,Zhou, Xiang-Dong,Zhou, Wei-Shan
, p. 3257 - 3259 (2003)
(Matrix presented) A short and highly stereoselective synthesis of the novel steroid squalamine (1) was accomplished in nine steps from easily available methyl chenodeoxylcholanate 2. Our synthesis featured improved dehydrogenation of 4 followed by conjugate reduction to construct the trans AB-ring system and efficient asymmetric isopropylation of aldehyde 6 to introduce the C-24R-hydroxyl group.