61033-69-0

Basic information

• Product Name: 1H-IMidazole, 4,5-dihydro-2-(2-cholrophenyl)-
• Synonyms: 1H-IMidazole, 4,5-dihydro-2-(2-cholrophenyl)-;2-(2-chlorophenyl)-4,5-dihydro-1H-Imidazole
• CAS NO: 61033-69-0
• Molecular Formula: C₉H₉ClN₂
• Molecular Weight: 180.63416
• Mol File: 61033-69-0.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-IMidazole, 4,5-dihydro-2-(2-cholrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-IMidazole, 4,5-dihydro-2-(2-cholrophenyl)-(61033-69-0)
• EPA Substance Registry System: 1H-IMidazole, 4,5-dihydro-2-(2-cholrophenyl)-(61033-69-0)

Safety Data

• Hazardous Substances Data: 61033-69-0(Hazardous Substances Data)

Usage

Description

1H-Imidazole, 4,5-dihydro-2-(2-chlorophenyl)-, also known as 1H-Imidazole, is a chemical compound with the molecular formula C9H9ClN2. It is an imidazole derivative featuring a chlorine-substituted phenyl group. 1H-IMidazole, 4,5-dihydro-2-(2-cholrophenyl)has potential applications in pharmaceuticals due to its relation to other imidazole compounds with antimicrobial and antifungal properties. Additionally, imidazole derivatives are utilized in the synthesis of various drugs and bioactive molecules, making 1H-Imidazole a promising candidate for the development of new pharmaceutical agents or research in imidazole-based chemistry.

Uses

Used in Pharmaceutical Industry:
1H-Imidazole, 4,5-dihydro-2-(2-chlorophenyl)is used as a pharmaceutical agent for its potential antimicrobial and antifungal properties. Its relation to other imidazole compounds with these properties makes it a valuable compound for the development of new treatments and therapies.
Used in Drug Synthesis:
1H-Imidazole, 4,5-dihydro-2-(2-chlorophenyl)is used as a key intermediate in the synthesis of various drugs and bioactive molecules. Its unique structure and functional groups make it a versatile building block for creating new pharmaceutical compounds with diverse therapeutic applications.
Used in Research and Development:
1H-Imidazole, 4,5-dihydro-2-(2-chlorophenyl)is used as a research compound for studying imidazole-based chemistry. Its potential applications in the development of new pharmaceutical agents and understanding the mechanisms of action of imidazole compounds make it an important tool for scientific investigation and discovery.

Upstream product

• 89-98-5 2-chloro-benzaldehyde 
• 107-15-3 ethylenediamine 
• 873-32-5 2-Chlorobenzonitrile 
• 76065-92-4 2-(2-chloro-phenyl)-imidazolidine 
• 15717-17-6 2-chlorothiobenzamide 

Downstream Products

• 76875-22-4 2-(o-chlorophenyl)-2-imidazoline 

Relevant articles and documents

Ligandless Nickel-Catalyzed Ortho-Selective Directed Trifluoromethylthiolation of Aryl Chlorides and Bromides Using AgSCF3

A mild protocol for Ni-catalyzed trifluoromethylthiolation of aryl chlorides and bromides is described herein. The method utilizes AgSCF3 as an easily accessible nucleophilic trifluoromethylthiolating reagent and does not require any ligands or additives. Ortho-selectivity is achieved using a variety of directing groups such as imines, pyridines, and oxazolines for 24 examples in up to 95% yield.

Ultrasound promoted synthesis of 2-imidazolines in water: A greener approach toward monoamine oxidase inhibitors

A series of sixteen 2-substituted-2-imidazolines (where the substituent R = Ph, Me-4-Ph; MeO-4-Ph; (MeO)2-3,4-Ph; (MeO)3-3,4,5-Ph; Ph-4-O-C(O)-Ph; Cl-4-Ph; Cl-2-Ph; Cl2-2,4-Ph; NO2-4-Ph; NO2-3-Ph; Naphth-2-yl; Fur-2-yl; Benzofur-2-yl; Pyridin-2-yl; Quinolin-2-yl) has been synthesized from the reaction of the substituted-aldehydes and ethylenediamine by ultrasound irradiation with NBS in an aqueous medium in high yields (80-99%). The 2-imidazoline ability to inhibit the activity of the A and B isoforms of monoamine oxidase (MAO) was investigated and some of them showed potent and selective MAO inhibitory activity especially for the MAO-B isoform and could become promising candidates for future development.

Direct oxidative conversion of aldehydes and alcohols to 2-imidazolines and 2-oxazolines using molecular iodine

Aldehydes were converted to the corresponding 2-imidazolines and 2-oxazolines in good yields by the reaction with ethylenediamine and aminoethanol, respectively, using molecular iodine and potassium carbonate. Moreover, primary alcohols were directly converted to the corresponding 2-imidazolines and 2-oxazolines via aldehydes in one-pot manner with ethylenediamine and aminoethanol, respectively, using molecular iodine and potassium carbonate.