61033-72-5

Basic information

• Product Name: 1H-IMidazole, 2-(2,4-dichlorophenyl)-4,5-dihydro-
• Synonyms: 1H-IMidazole, 2-(2,4-dichlorophenyl)-4,5-dihydro-;2-(2,4-Dichlorophenyl)-4,5-dihydro-1H-imidazole
• CAS NO: 61033-72-5
• Molecular Formula: C₉H₈Cl₂N₂
• Molecular Weight: 215.07922
• Mol File: 61033-72-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 98-100 °C
• Boiling Point: 156-158 °C(Press: 4 Torr)
• Appearance: /
• Density: 1.44±0.1 g/cm3(Predicted)
• PKA: 9.06±0.40(Predicted)
• CAS DataBase Reference: 1H-IMidazole, 2-(2,4-dichlorophenyl)-4,5-dihydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-IMidazole, 2-(2,4-dichlorophenyl)-4,5-dihydro-(61033-72-5)
• EPA Substance Registry System: 1H-IMidazole, 2-(2,4-dichlorophenyl)-4,5-dihydro-(61033-72-5)

Safety Data

• Hazardous Substances Data: 61033-72-5(Hazardous Substances Data)

Usage

General Description

1H-Imidazole, 2-(2,4-dichlorophenyl)-4,5-dihydro- is a chemical compound with the molecular formula C9H8Cl2N2. It is a derivative of imidazole, a five-membered heterocyclic ring containing two nitrogen atoms. 1H-Imidazole, 2-(2,4-dichlorophenyl)-4,5-dihydro- is used as an antifungal medication, particularly in the treatment of yeast infections and athlete's foot. It works by interfering with the production of ergosterol, an essential component of the fungal cell membrane, leading to disruption of the membrane's structure and function. As a result, the growth and replication of the fungus is inhibited, thereby treating the infection. This chemical is also used in research and laboratory settings as a tool for studying the effects of imidazole derivatives on biological processes.

Upstream product

• 874-42-0 2,4-dichlorobenzaldeyhde 
• 107-15-3 ethylenediamine 

Relevant articles and documents

Green Synthesis of 2-Substituted Imidazolines using Hydrogen Peroxide Catalyzed by Tungstophosphoric Acid and Tetrabutylammonium Bromide in Water

Various 2-substituted imidazolines were constructed from aromatic aldehydes with ethylenediamine using hydrogen peroxide as an oxidant in water. Tungstophosphoric acid (HPW) was found to be active for this transformation due to its ubiquitous catalytic and oxidative nature, and further combination of tetrabutylammonium bromide (TBAB) made this transformation more efficient and attractive. It was found that the yields of the corresponding 2-substituted imidazolines were markedly influenced by the position and nature of the substituents on the phenyl ring. A plausible mechanism was also proposed to clarify this catalytic oxidative system.

Efficient synthesis of 2-imidazolines in the presence of molecular iodine under ultrasound irradiation

An efficient one-pot synthesis process for preparing 2-imidazolines from aldehydes and ethylenediamine using molecular iodine and potassium carbonate in absolute ethanol at 25-30°C under ultrasound irradiation is described. The synthetic strategy has the following advantages: mild conditions and low costs requirements, readily available catalyst, short reaction times, simplicity of operation, and good-to-excellent yields.

A facile and efficient synthesis of 2-imidazolines from aldehydes using hydrogen peroxide and substoichiometric sodium iodide

The reaction of aldehydes with ethylenediamine for the preparation of 2-imidazolines has been studied using hydrogen peroxide as an oxidant in the presence of sodium iodide and anhydrous magnesium sulfate. A mild, green, and efficient method is established to carry out this reaction in high yield. Georg Thieme Verlag Stuttgart · New York.