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61036-62-2

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Teicoplanin
Cas No: 61036-62-2
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-10 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
Teicoplanin
Cas No: 61036-62-2
No Data No Data No Data CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD Contact Supplier
Teicoplanin /61036-62-2 /with high purity 99% in stock
Cas No: 61036-62-2
USD $ 10.0-10.0 / Gram 1 Gram 1000 Gram/Day Shenzhen Tianyuan Pharmaceutical Technology Co., Ltd Contact Supplier
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Cas No: 61036-62-2
USD $ 10.0-10.0 / Gram 1 Gram 10 Kilogram/Day Hubei Vanz Pharm Co.,Ltd Contact Supplier
Teicoplanin
Cas No: 61036-62-2
No Data No Data No Data Shanghai Yanchu chemicals Co., Ltd Contact Supplier
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Cas No: 61036-62-2
USD $ 12.0-20.0 / Gram 1 Gram 99999 Kilogram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
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Cas No: 61036-62-2
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Cas No: 61036-62-2
USD $ 20.0-25.0 / Gram 10 Gram 20 Kilogram/Month Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
Factory Price API 99% Teicoplanin 61036-62-2 GMP Manufacturer
Cas No: 61036-62-2
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier

61036-62-2 Usage

Mode of action

Once the muramylpentapeptide is formed in the cell cytoplasm, an N-acetylglucosamine unit is added, together with any amino acids needed for the interpeptide bridge of Grampositive organisms. It is then passed to a lipid carrier molecule, which transfers the whole unit across the cell membrane to be added to the growing end of the peptidoglycan macromolecule. Addition of the new building block (transglycosylation) is prevented by teicoplanin which bind to the acyl-d-alanyl-d-alanine tail of the muramylpentapeptide. Because antibiotics are large polar molecules, they cannot penetrate the outer membrane of Gramnegative organisms, which explains their restricted spectrum of activity.

Description

Teicoplanin is a new antibiotic, the second glycopeptide to be developed in over 30 years. Compared with vancomycin, the only such agent currently available, teicoplanin is equiefficacious, and has milder side-effects and a longer half-life, allowing once-daily dosing and bolus injection. Teicoplanin is claimed to have an overall cure rate of 92% in infections involving skin, joint and bone, endocaditis and septicemia.

Chemical Properties

Yellowish, amorphous powder.

Originator

Merrell Dow (Italy)

Uses

anticonvulsant, antipsychotic

Uses

Teicoplanin complex is family of closely related metabolites produced by Actinoplanes teichomyceticus. Teicoplanin complex possesses potent broad spectrum antibiotic activity against Gram positive bacteria, including MRSA and E. faecalis. The metabolites share a common glycopeptide core (teicoplanin A-3) on which a family of fatty acids varying in length, degree of saturation and branching are linked as amides through one of the aminoglycoside moieties. The major component of the complex is teicoplanin A2 which itself has five major components (teicoplanin A2-1 to A2-5) and four minor components (teicoplanin RS-1 to RS-4).

Uses

antidepressant

Brand name

Targocid

General Description

Teicoplanin (Teichomycin A2, Targocid) is a mixture offive closely related glycopeptide antibiotics produced bythe actinomycete Actinoplanes teichomyceticus. The teicoplanin factors differ only in the acyl group inthe northernmost of two glucosamines glycosidicallylinked to the cyclic peptide aglycone. Another sugar, Dmannose,is common to all of the teicoplanins. Thestructures of the teicoplanin factors were determined independentlyby a combination of chemical degradationand spectroscopic methods in three different groupsin 1984. The teicoplanin complex is similar to vancomycin structurallyand microbiologically but has unique physical propertiesthat contribute some potentially useful advantages.While retaining excellent water solubility, teicoplanin has significantlygreater lipid solubility than vancomycin. Thus, teicoplaninis distributed rapidly into tissues and penetratesphagocytes well. The complex has a long elimination halflife,ranging from 40 to 70 hours, resulting from a combinationof slow tissue release and a high fraction of protein bindingin the plasma (~90%). Unlike vancomycin, teicoplanin isnot irritating to tissues and may be administered by intramuscularor intravenous injection. Because of its long half-life, teicoplaninmay be administered on a once-a-day dosing schedule.Orally administered teicoplanin is not absorbedsignificantly and is recovered 40% unchanged in the feces.Teicoplanin exhibits excellent antibacterial activity againstGram-positive organisms, including staphylococci, streptococci,enterococci, Clostridium and Corynebacterium spp.,Propionibacterium acnes, and L. monocytogenes. It is not activeagainst Gram-negative organisms, including Neisseriaand Mycobacterium spp. Teicoplanin impairs bacterial cellwall synthesis by complexing with the terminal D-alanine-Dalaninedipeptide of the peptidoglycan, thus preventing crosslinkingin a manner entirely analogous to the action ofvancomycin.

Clinical Use

Antibacterial agent.

Drug interactions

Potentially hazardous interactions with other drugs None known

Metabolism

Teicoplanin is excreted almost entirely by glomerular filtration in the urine, as unchanged drug. Two metabolites are formed probably by hydroxylation and represents 2-3% of the administered dose. Unchanged teicoplanin is mainly excreted by the urinary route while 2.7% of the administered dose is recovered in feces (via bile excretion) within 8 days following administration.
InChI:InChI=1/C88H95Cl2N9O33/c1-3-4-5-6-7-8-9-10-60(108)94-68-74(113)71(110)58(32-101)129-87(68)132-78-55-26-40-27-56(78)126-52-18-14-38(24-47(52)90)77(131-86-67(92-34(2)103)73(112)70(109)57(31-100)128-86)69-84(121)98-66(85(122)123)45-29-42(105)30-54(127-88-76(115)75(114)72(111)59(33-102)130-88)61(45)44-23-37(13-15-49(44)106)63(81(118)99-69)96-83(120)65(40)97-82(119)64-39-21-41(104)28-43(22-39)124-53-25-36(12-16-50(53)107)62(91)80(117)93-48(79(116)95-64)20-35-11-17-51(125-55)46(89)19-35/h7-8,11-19,21-30,48,57-59,62-77,86-88,100-102,104-107,109-115H,3-6,9-10,20,31-33,91H2,1-2H3,(H,92,103)(H,93,117)(H,94,108)(H,95,116)(H,96,120)(H,97,119)(H,98,121)(H,99,118)(H,122,123)/b8-7+/t48?,57-,58-,59-,62-,63-,64+,65-,66+,67-,68-,69+,70-,71-,72-,73-,74-,75+,76+,77-,86+,87+,88?/m1/s1

61036-62-2 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma-Aldrich (Y0001102)  Teicoplanin  European Pharmacopoeia (EP) Reference Standard 61036-62-2 Y0001102 1,880.19CNY Detail
Sigma-Aldrich (Y0001047)  Teicoplanin for identification  European Pharmacopoeia (EP) Reference Standard 61036-62-2 Y0001047 1,880.19CNY Detail

61036-62-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name Telicoplanin

1.2 Other means of identification

Product number -
Other names TEICOPLANIN,JP

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:61036-62-2 SDS

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