61036-62-2 Usage
Uses
Used in Pharmaceutical Industry:
Teicoplanin is used as an antibiotic for its potent broad-spectrum activity against Gram-positive bacteria, including MRSA and E. faecalis. Its milder side-effects and longer half-life make it a preferred choice for treating various infections.
Used in Anticonvulsant Applications:
Teicoplanin is used as an anticonvulsant, helping to control and prevent seizures in patients with epilepsy or other seizure disorders.
Used in Antipsychotic Applications:
Teicoplanin is used as an antipsychotic, aiding in the management of psychiatric conditions such as schizophrenia, bipolar disorder, and other related mental health disorders.
Used in Antidepressant Applications:
Teicoplanin is used as an antidepressant, assisting in the treatment of depression and related mood disorders by helping to regulate mood and alleviate symptoms.
Teicoplanin Complex:
The Teicoplanin complex is a family of closely related metabolites produced by Actinoplanes teichomyceticus. These metabolites share a common glycopeptide core (teicoplanin A-3) on which a family of fatty acids varying in length, degree of saturation, and branching are linked as amides through one of the aminoglycoside moieties. The major component of the complex is teicoplanin A2, which itself has five major components (teicoplanin A2-1 to A2-5) and four minor components (teicoplanin RS-1 to RS-4).
Mode of action
Once the muramylpentapeptide is formed in the cell cytoplasm, an N-acetylglucosamine unit is added, together with any amino acids needed for the interpeptide bridge of Grampositive organisms. It is then passed to a lipid carrier molecule, which transfers the whole unit across the cell membrane to be added to the growing end of the peptidoglycan macromolecule. Addition of the new building block (transglycosylation) is prevented by teicoplanin which bind to the acyl-d-alanyl-d-alanine tail of the muramylpentapeptide. Because antibiotics are large polar molecules, they cannot penetrate the outer membrane of Gramnegative organisms, which explains their restricted spectrum of activity.
Originator
Merrell Dow (Italy)
Clinical Use
Antibacterial agent.
Drug interactions
Potentially hazardous interactions with other drugs
None known
Metabolism
Teicoplanin is excreted almost entirely by glomerular
filtration in the urine, as unchanged drug. Two
metabolites are formed probably by hydroxylation and
represents 2-3% of the administered dose. Unchanged
teicoplanin is mainly excreted by the urinary route while
2.7% of the administered dose is recovered in feces (via
bile excretion) within 8 days following administration.
Check Digit Verification of cas no
The CAS Registry Mumber 61036-62-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,0,3 and 6 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 61036-62:
(7*6)+(6*1)+(5*0)+(4*3)+(3*6)+(2*6)+(1*2)=92
92 % 10 = 2
So 61036-62-2 is a valid CAS Registry Number.
InChI:InChI=1/C88H95Cl2N9O33/c1-3-4-5-6-7-8-9-10-60(108)94-68-74(113)71(110)58(32-101)129-87(68)132-78-55-26-40-27-56(78)126-52-18-14-38(24-47(52)90)77(131-86-67(92-34(2)103)73(112)70(109)57(31-100)128-86)69-84(121)98-66(85(122)123)45-29-42(105)30-54(127-88-76(115)75(114)72(111)59(33-102)130-88)61(45)44-23-37(13-15-49(44)106)63(81(118)99-69)96-83(120)65(40)97-82(119)64-39-21-41(104)28-43(22-39)124-53-25-36(12-16-50(53)107)62(91)80(117)93-48(79(116)95-64)20-35-11-17-51(125-55)46(89)19-35/h7-8,11-19,21-30,48,57-59,62-77,86-88,100-102,104-107,109-115H,3-6,9-10,20,31-33,91H2,1-2H3,(H,92,103)(H,93,117)(H,94,108)(H,95,116)(H,96,120)(H,97,119)(H,98,121)(H,99,118)(H,122,123)/b8-7+/t48?,57-,58-,59-,62-,63-,64+,65-,66+,67-,68-,69+,70-,71-,72-,73-,74-,75+,76+,77-,86+,87+,88?/m1/s1
