61044-94-8

Basic information

• Product Name: 4-Hydroxy-5-chloro-2-methylthiopyrimidine
• Synonyms: 4-Hydroxy-5-chloro-2-methylthiopyrimidine;5-Chloro-2-(methylthio)-4(3H)-pyrimidinone;5-CHLORO-2-METHYLSULFANYL-PYRIMIDIN-4-OL;5-chloro-2-(methylthio)pyrimidin-4(3H)-one
• CAS NO: 61044-94-8
• Molecular Formula: C₅H₅ClN₂OS
• Molecular Weight: 177
• Mol File: 61044-94-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: 258-260℃
• Appearance: /
• Density: 1.54
• CAS DataBase Reference: 4-Hydroxy-5-chloro-2-methylthiopyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxy-5-chloro-2-methylthiopyrimidine(61044-94-8)
• EPA Substance Registry System: 4-Hydroxy-5-chloro-2-methylthiopyrimidine(61044-94-8)

Safety Data

• Hazardous Substances Data: 61044-94-8(Hazardous Substances Data)

Upstream product

• 5751-20-2 2-Methylthiouracil 
• 128-09-6 N-chloro-succinimide 

Downstream Products

• 269055-66-5 4-[(5-chloro-4-hydroxy-2-pyrimidinyl)amino]benzonitrile 
• 107403-27-0 5-chloro-4-iodo-2-methylthiopyrimidine 
• 99469-85-9 4,5-dichloro-2-(methylsulfanyl)pyrimidine 

Relevant articles and documents

PYRIDINE- 2- DERIVATIVES AS SMOOTHENED RECEPTOR MODULATORS

The present application relates to compounds of Formula (I), and Formula (II), or pharmaceutically acceptable salt thereof, wherein A, X, Y, Z, e, f, R1, R2, R3, R4, R5, R5b, R6, R7, R8, R9, R10, R11,R20, R21, R22 and R23 are defined herein. These novel pyridine derivatives that are useful in therapy, in particular for treating diseases or conditions mediated by Smo, including the treatment of abnormal cell growth, such as cancer, in mammals. Additional embodiments relate to methods of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.