107403-27-0

Upstream product

• 99469-85-9 4,5-dichloro-2-(methylsulfanyl)pyrimidine 
• 5751-20-2 2-Methylthiouracil 
• 61044-94-8 5-chloro-2-methylthio-4(1H)-pyrimidinone 

Downstream Products

• 118506-77-7 5-chloro-2-methylthio-4-β-trans-styrylpyrimidine 
• 118506-84-6 5-chloro-2-methylthio-4-phenylpyrimidine 
• 118506-86-8 4-benzyl-5-chloro-2-methylthiopyrimidine 
• 118506-81-3 cis-5-chloro-2-methylthio-4-propenylpyrimidine 
• 118506-79-9 5-chloro-2-methylthio-4-cis-β-styrylpyrimidine 
• 107403-28-1 5-chloro-2-methylthio-4-(phenylethynyl)pyrimidine 

Relevant academic research and scientific papers

PYRIDINE- 2- DERIVATIVES AS SMOOTHENED RECEPTOR MODULATORS

The present application relates to compounds of Formula (I), and Formula (II), or pharmaceutically acceptable salt thereof, wherein A, X, Y, Z, e, f, R1, R2, R3, R4, R5, R5b, R6, R7, R8, R9, R10, R11,R20, R21, R22 and R23 are defined herein. These novel pyridine derivatives that are useful in therapy, in particular for treating diseases or conditions mediated by Smo, including the treatment of abnormal cell growth, such as cancer, in mammals. Additional embodiments relate to methods of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

Palladium Catalysis in the Preparation of Alkynylpyrimidines

4-Ethynyl derivatives of 5-chloro-2-methylthiopyrimidines, and of 5-chloro-2(1H)-pyrimidinones as trimethylsilyl derivatives, have been prepared by cross-coupling reactions between 4-iodopyrimidines and acetylenes using palladium catalysis.Reactions for t