61054-60-2

Basic information

• Product Name: 3’,5’-dimethoxy-5,6-dihydro-[1,1’-biphenyl]-3(4H)-one
• Synonyms: 3’,5’-dimethoxy-5,6-dihydro-[1,1’-biphenyl]-3(4H)-one
• CAS NO: 61054-60-2
• Molecular Weight: 232.279
• Mol File: 61054-60-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3’,5’-dimethoxy-5,6-dihydro-[1,1’-biphenyl]-3(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3’,5’-dimethoxy-5,6-dihydro-[1,1’-biphenyl]-3(4H)-one(61054-60-2)
• EPA Substance Registry System: 3’,5’-dimethoxy-5,6-dihydro-[1,1’-biphenyl]-3(4H)-one(61054-60-2)

Safety Data

• Hazardous Substances Data: 61054-60-2(Hazardous Substances Data)

Upstream product

• 504-02-9 1,3-cylohexanedione 
• 56671-81-9 3-bromo-2-cyclohexen-1-one 
• 192182-54-0 3,5-dimethoxyphenylboronic acid 
• 20469-65-2 1-bromo-3,5-dimethoxybenzene 
• 58529-72-9 3-isopropoxycyclohex-2-en-1-one 
• 5323-87-5 3-Ethoxycyclohex-2-en-1-one 
• 5682-75-7 3-chloro-2-cyclohexenone 

Downstream Products

• 1374219-32-5 7-(3,5-dimethoxyphenyl)-1,4-dioxaspiro[4.5]decan-8-one 
• 1374219-36-9 (7S,8S)-7-(3,5-dimethoxyphenyl)-1,4-dioxaspiro[4.5]decan-8-ol 
• 868666-20-0 3',5'-trimethoxy-biphenyl-3-ol 
• 61054-69-1 1-(3,5-Dimethoxy-phenyl)-3-oxo-cyclohexanecarboxylic acid methyl ester 

Relevant articles and documents

AROMATIC DERIVATIVES, PREPARATION METHODS, AND MEDICAL USES THEREOF

The present disclosure relates generally to aromatic derivatives that are inhibitors of FGFR4 and are useful in treating FGFR4-associated diseases or conditions. Compositions containing the compounds of the present disclosure are also provided.

Enantioselective synthesis of (-)-CP-55940 via ruthenium-catalyzed asymmetric hydrogenation of ketones

A new and efficient catalytic asymmetric synthesis of the potent cannabinoid receptor agonist (-)-CP-55940 has been developed by using ruthenium-catalyzed asymmetric hydrogenation of racemic α-aryl ketones via dynamic kinetic resolution (DKR) as a key step. With RuCl2-SDPs/ diamine [SDPs=7,7'-bis(diarylphophino)-1,1'-spirobiindane] catalysts the asymmetric hydrogenation of racemic α-arylcyclohexanones via DKR provided the corresponding cis-β-arylcyclohexanols in high yields with up to 99.3% ee and >99:1 cis-selectivities. Both ethylene ketal group at the cyclohexane ring and ortho-methoxy group at the phenyl ring of the substrates 6 have little effect on the selectivity and reactivity of the hydrogenations. Based on this highly efficient asymmetric ketone hydrogenation, (-)-CP-55940 was synthesized in 13 steps (the longest linear steps) in 14.6% overall yield starting from commercially available 3-methoxybenzaldehyde and 1,4-cyclohexenedione monoethylene acetal. Copyright