868666-20-0

Upstream product

• 192182-54-0 3,5-dimethoxyphenylboronic acid 
• 61054-60-2 3’,5’-dimethoxy-5,6-dihydro-[1,1’-biphenyl]-3(4H)-one 
• 67-56-1 methanol 
• 20511-03-9 4-(3’-hydroxyphenyl)-3(E)-buten-2-one 
• 108-59-8 malonic acid dimethyl ester 

Relevant academic research and scientific papers

Convenient Access to meta-Substituted Phenols by Palladium-Catalyzed Suzuki–Miyaura Cross-Coupling and Oxidation

We report a new approach to the synthesis of meta-substituted phenols in which a single palladium catalyst accomplishes a Suzuki–Miyaura cross-coupling between a β-chlorocyclohexenone and an arylboronic acid, and oxidation of the resulting cyclohexenone to the corresponding phenol upon introduction of a terminal oxidant and electron transfer mediator. Notably, this method also allows ready access to ortho, meta-disubstituted phenols, sterically congested biaryl phenols, and more highly substituted phenols.

Regioselectivity of birch reductive alkylation of biaryls

(Chemical Equation Presented) The regioselectivity of the Birch reductive alkylation of polysubstituted biaryls has been investigated. Results indicate that regioselectivity is affected by the electronic nature of substituents on both aromatic rings. The