61064-76-4

Upstream product

• 501082-84-4 {(S)-2-[2-(2-{(S)-2-tert-Butoxycarbonylamino-3-[4-(2,6-dichloro-benzyloxy)-phenyl]-propionylamino}-acetylamino)-acetylamino]-3-phenyl-propionylamino}-acetic acid methyl ester 
• 501082-72-0 Boc-Tyr(2,6-Cl₂Bzl)-Gly-Gly-Phe-OH 
• 501082-71-9 Boc-Tyr(2,6-Cl₂Bzl)-Gly-Gly-Phe-OMe 
• 501082-86-6 [(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-acetic acid methyl ester 

Relevant academic research and scientific papers

Studies on the synthesis of estrogen-GHRPS linkers

A series of linkers consisted of estrone, estradiol, and GHRPS (growth hormone releasing peptides) were prepared with carboxyl-methyl or succinyl as the conjugated group. As a protective group in the side chain of Tyr, the Dcb (2,6-dichlorobenzyl) in the intermediates which is unstable to HF can be removed in high yield in the presence of Pd/C (10%), H2, and 4.4% formic acid in methanol.