501082-72-0

Upstream product

• 19240-24-5 N--L-3-phenylalanine methyl ester hydrochloride 
• 61131-29-1 N-glycyl>-L-3-phenylalanine methyl ester hydrochloride 
• 63631-32-3 (S)-methyl 12-benzyl-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate 
• 106624-70-8 methyl (2S)-2-[[2-(t-butoxycarbonylamino)acetyl]amino]-3-phenylpropanoate 
• 501082-71-9 Boc-Tyr(2,6-Cl₂Bzl)-Gly-Gly-Phe-OMe 

Downstream Products

• 501082-80-0 Boc-Tyr(2,6-Cl₂Bzl)-Gly-Gly-Phe-Leu-NH₂ 
• 501082-79-7 Boc-Tyr(2,6-Cl₂Bzl)-Gly-Gly-Phe-Leu-OMe 
• 501082-85-5 {(S)-1-{[({[(S)-1-(Carbamoylmethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-methyl]-carbamoyl}-2-[4-(2,6-dichloro-benzyloxy)-phenyl]-ethyl}-carbamic acid tert-butyl ester 
• 501082-84-4 {(S)-2-[2-(2-{(S)-2-tert-Butoxycarbonylamino-3-[4-(2,6-dichloro-benzyloxy)-phenyl]-propionylamino}-acetylamino)-acetylamino]-3-phenyl-propionylamino}-acetic acid methyl ester 
• 521060-85-5 C₅₅H₆₆Cl₂N₆O₉ 
• 501082-91-3 2-[2-(2-{2-[2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid 3-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester 
• 501083-05-2 C₅₃H₆₀Cl₂N₆O₁₀ 
• 501083-26-7 C₅₅H₆₆Cl₂N₆O₉ 
• 501083-25-6 C₅₆H₆₇Cl₂N₅O₁₀ 
• 501082-90-2 C₅₄H₆₃Cl₂N₅O₁₀ 
• 501083-31-4 C₅₂H₅₉Cl₂N₅O₁₀ 
• 501083-22-3 estrone-3-O-CH₂CO-Tyr(2,6-dichlorobenzyl)-Gly-Gly-Phe-Gly-OMe 
• 501083-32-5 C₅₁H₅₈Cl₂N₆O₉ 
• 501083-23-4 estrone-3-O-CH₂CO-Tyr(2,6-dichlorobenzyl)-Gly-Gly-Phe-Gly-NH₂ 

Relevant academic research and scientific papers

Studies on the synthesis and anti-Osteoporosis of estrogen-GHRPs linkers.

The linkers of estrogen-GHRPs were prepared by the combination of estradiol, estrone, TyrGlyGlyPheLeuOH, and TyrGlyGlyPheLeuOH. Their anti-osteoporosis effect was evaluated by analyzing the data, for instance the weight of the body, femur, femur ash, the content of calcium and phosphor in the femur, the content of calcium and ALP activity in the serum, obtained from the corresponding bioassay in vivo. The results indicated that the anti-osteoporosis potency for estradiol, estrone, TyrGlyGlyPheLeuOH and TyrGlyGlyPheLeuNH(2) may be totally enhanced each other via the corresponding linkers.

Studies on the synthesis of estrogen-GHRPS linkers

A series of linkers consisted of estrone, estradiol, and GHRPS (growth hormone releasing peptides) were prepared with carboxyl-methyl or succinyl as the conjugated group. As a protective group in the side chain of Tyr, the Dcb (2,6-dichlorobenzyl) in the intermediates which is unstable to HF can be removed in high yield in the presence of Pd/C (10%), H2, and 4.4% formic acid in methanol.