61077-41-6Relevant academic research and scientific papers
Labelling of a new hypolipaemic agent with carbon 14, preparation of 1,1 bis[4 (1 carboxy 1 methylpropoxy)phenyl]cyclohexane 2 14C
Yoshitake,Makari,Kawahara,Doi
, p. 247 - 257 (1976)
1,1 Bis[4 (1 carboxy 1 methylpropoxy)phenyl] cyclohexane (S 8527) (I), a new hypolipemic agent, was labelled as C 2 with carbon 14 for the use of metabolic studies. Cyclohexane 2 14C which was prepared from potassium cyanide 14C was condensed with phenol to produce 1,1 bis(4 hydroxyphenyl)cyclohexane 2 14C (VI). Condensation of VI with ethyl methyl ketone and chloroform under a strong base (potassium hydroxide) gave S 8527 2 14C (I). A total of 3.11 mCi of pure S 8527 2 14C (I) was obtained, representing a 12% radiochemical yield from potassium cyanide 14C. Furthermore, a new radioactive by product was isolated and elucidated its structure as X.
