Labelling of a new hypolipaemic agent with carbon 14, preparation of 1,1 bis[4 (1 carboxy 1 methylpropoxy)phenyl]cyclohexane 2 14C

Article abstract of DOI:10.1002/jlcr.2580120213

1,1 Bis[4 (1 carboxy 1 methylpropoxy)phenyl] cyclohexane (S 8527) (I), a new hypolipemic agent, was labelled as C 2 with carbon 14 for the use of metabolic studies. Cyclohexane 2 ¹⁴C which was prepared from potassium cyanide ¹⁴C was condensed with phenol to produce 1,1 bis(4 hydroxyphenyl)cyclohexane 2 ¹⁴C (VI). Condensation of VI with ethyl methyl ketone and chloroform under a strong base (potassium hydroxide) gave S 8527 2 ¹⁴C (I). A total of 3.11 mCi of pure S 8527 2 ¹⁴C (I) was obtained, representing a 12% radiochemical yield from potassium cyanide ¹⁴C. Furthermore, a new radioactive by product was isolated and elucidated its structure as X.