610797-48-3Relevant academic research and scientific papers
NOVEL SUBSTITUTED ARYL DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES AS ANTI-HIV AGENTS
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Page/Page column 78, (2010/06/22)
The present invention concerns novel substituted aryl derivatives, their process of preparation and their use for inhibiting virus replication and for treating viral diseases or disorders such as HIV and/or HCV infection.
Ruthenium olefin metathesis catalysts with modified styrene ethers: Influence of steric and electronic effects
Zaja, Mirko,Connon, Stephen J.,Dunne, Aideen M.,Rivard, Michael,Buschmann, Nicole,Jiricek, Jan,Blechert, Siegfried
, p. 6545 - 6558 (2007/10/03)
A series of olefin metathesis catalysts with modified isopropoxybenzylidene ligands were synthesised, and the effects of ligands on the rate of metathesis investigated. Increased steric hinderance ortho to the isopropoxy group enhanced reaction rates. In the case of N-heterocyclic carbene complexes, decreasing electron density at both the chelating oxygen atom and the Ru=C bond accelerated reaction rates appreciably. Catalysts containing a tricyclohexylphosphane ligand, followed the same trend with regard to benzylidene electrophilicity, while higher electron density at oxygen enhanced reaction rates.
