61085-35-6Relevant academic research and scientific papers
Antiinflammatory Agents. 2. Syntheses and Antiinflammatory Activity of Substituted 2-Aminophenylacetic Acid Derivatives
Walsh, David A.,Shamblee, Dwight A.,Welstead, William J.,Sancilio, Lawrence F.
, p. 446 - 451 (2007/10/02)
Several substituted 2-aminophenylacetic acid derivatives were prepared and tested for in vitro prostaglandin synthetase inhibition and for in vivo antiinflammatory activity.The 2-amino substituent is beneficial to potency in the inhibition of prostaglandin synthetase for the 3-phenoxy, 4-phenyl, and 3-benzoyl series, but only 3-benzoyl series shows increased antiinflammatory potency in the in vivo assay.
4-(5- And 7-)benzoylindolin-2-ones and pharmaceutical uses thereof
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, (2008/06/13)
Novel 4-(5- and 7-)benzoylindolin-2-ones of the formula: SPC1 Wherein R is hydrogen, lower-alkyl, or methylthio, R1 is hydrogen or lower-alkyl, R2 is lower-alkyl, lower-alkoxy, halogen, nitro or trifluoromethyl, R3 is hydrogen, halogen or lower-alkoxy, and n is 0, 1 or 2, are prepared by (a) acylation of indolin-2-one to give 5-benzoylindoline-2-one, (b) cyclization of 2-acetamido-3-benzoylphenylacetic acid or ethyl 2-acetamido-3-benzoylphenylacetate to give 7-benzoyindoline-2-one, or (c) by reacting aminobenzophenones with alkyl α(methylthio)acetates to give alkyl 2-amino-3-(5- or 6-)benzoyl-α-(methylthio)phenylacetates which are cyclized and demethylthiolated to 4-(5- and 7-)benzoylindolin-2-ones. The novel compounds possess anti-inflammatory activity and are intermediates for the preparation of 2-amino-3-(5- or 6-) benzoylphenylacetic acids which posess anti-inflammatory properties.
