61941-64-8Relevant academic research and scientific papers
Antiinflammatory Agents. 2. Syntheses and Antiinflammatory Activity of Substituted 2-Aminophenylacetic Acid Derivatives
Walsh, David A.,Shamblee, Dwight A.,Welstead, William J.,Sancilio, Lawrence F.
, p. 446 - 451 (2007/10/02)
Several substituted 2-aminophenylacetic acid derivatives were prepared and tested for in vitro prostaglandin synthetase inhibition and for in vivo antiinflammatory activity.The 2-amino substituent is beneficial to potency in the inhibition of prostaglandin synthetase for the 3-phenoxy, 4-phenyl, and 3-benzoyl series, but only 3-benzoyl series shows increased antiinflammatory potency in the in vivo assay.
