6109-35-9

Basic information

• Product Name: 4-Phenyl-1,2,3,4-tetrahydroisoquinoline Hydrochloride
• Synonyms: 1,2,3,4-Tetrahydro-4-phenyl-isoquinoline Hydrochloride
• CAS NO: 6109-35-9
• Molecular Formula: C₁₅H₁₅N*ClH
• Molecular Weight: 245.74724
• Product Categories: Aromatics;Inhibitors
• Mol File: 6109-35-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Phenyl-1,2,3,4-tetrahydroisoquinoline Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Phenyl-1,2,3,4-tetrahydroisoquinoline Hydrochloride(6109-35-9)
• EPA Substance Registry System: 4-Phenyl-1,2,3,4-tetrahydroisoquinoline Hydrochloride(6109-35-9)

Safety Data

• Hazardous Substances Data: 6109-35-9(Hazardous Substances Data)

Usage

Uses

An inhibitor of release of dopamine induced by methamphetamine.

Upstream product

• 75626-12-9 4-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 133390-58-6 2-(o-aminobenzyl)-4-phenyl-1,2,3,4-tetrahydroisoquinoline dihydrochloride 

Downstream Products

• 151724-11-7 1-(4-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)ethanone 

Relevant articles and documents

Weinreb amide based synthetic equivalents for convenient access to 4-aryl-1,2,3,4-tetrahydroisoquinolines

New synthetic equivalents, N-methoxy-N-methyl-N′-phenylsulfonyl glycinamide and N-methoxy-N-methyl-N′-benzyl-N′-tert-butyloxy carbonyl glycinamide based on WA functionality were developed for the convenient synthesis of 4-aryl-1,2,3,4-tetrahydroisoquinoline framework. Two simple reactions, N-benzylation and addition of arylmagnesium halide on the WA functionality of the former afforded the key intermediate for convenient synthesis of N-phenylsulfonyl protected 4-aryl-1,2,3,4-tetrahydroisoquinoline, through reduction and acid promoted cyclization. With the latter, the addition of arylmagnesium halide on the WA functionality followed by the same protocol afforded the direct synthesis of 4-aryl-1,2,3,4-tetrahydroisoquinolines in good yields. The acid promoted cyclization step enabled concomitant removal of N-Boc protection.