611199-75-8

Upstream product

• 874-23-7 2-acetylcyclohexanone 
• 78-94-4 methyl vinyl ketone 
• 340161-40-2 N-(2-Acetyl-1-cyclohexenyl)-L-valine diethylamide 
• 28329-46-6 2,2-difluoro-4-methyl-5,6,7,8-tetrahydro-2H-2λ⁴,3λ³-benzo[d][1,3,2]dioxaborinine 

Relevant academic research and scientific papers

Generation of quaternary stereocenters by asymmetric Michael reactions: Enamine regiochemistry as configuration switch

Regioselective enamine formation from cyclic β-diketones 1 is obtained by the appropriate choice of activating agent: Bronsted acid catalyzed condensation gives endocyclic enamines 3 as the thermodynamically favored products. Activation with Lewis acid BF

Regioselective enamine formation from oxonia-boranuida-betaines and their application in asymmetric Michael reactions

β-Diketonato borate betaines 2 are readily accessible by the reaction of β-dicarbonyl compounds 1 with BF3·OEt2. Reaction of borates 2 with L-valine diethylamide (3a) gives almost exclusively the exocyclic enamines 4 as the kinetic p