611212-85-2Relevant academic research and scientific papers
Design and synthesis of orally bioavailable benzimidazoles as raf kinase inhibitors
Ramurthy, Savithri,Subramanian, Sharadha,Aikawa, Mina,Amiri, Payman,Costales, Abran,Dove, Jeff,Fong, Susan,Jansen, Johanna M.,Levine, Barry,Ma, Sylvia,McBride, Christopher M.,Michaelian, Jonah,Pick, Teresa,Poon, Daniel J.,Girish, Sandhya,Shafer, Cynthia M.,Stuart, Darrin,Sung, Leonard,Renhowe, Paul A.
scheme or table, p. 7049 - 7052 (2009/11/30)
A series of arylaminobenzimidazoles was designed and synthesized as Raf kinase inhibitors. Exploration of the structure-activity relationship resulted in compounds that are potent in vitro and show desirable in vivo properties.
Substituted benzazoles and methods of their use as inhibitors of Raf kinase
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Page 23, (2008/06/13)
New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
