61137-48-2 Usage
Uses
Used in Anticancer Applications:
Lomustine is utilized as an anticancer agent for the treatment of various types of cancer, including brain tumors, Hodgkin's lymphoma, and multiple myeloma. Its effectiveness in treating brain tumors is attributed to its ability to cross the blood-brain barrier. Lomustine modulates the DNA replication process in cancer cells, thereby inhibiting their growth and proliferation.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, lomustine is used as a key component in the development of cancer treatment regimens. Its unique properties, such as the ability to cross the blood-brain barrier and its long half-life, make it a valuable asset in the fight against cancer. However, due to its potential for serious side effects, including bone marrow suppression and lung toxicity, the use of lomustine must be carefully monitored and administered under the supervision of a healthcare professional.
Check Digit Verification of cas no
The CAS Registry Mumber 61137-48-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,1,3 and 7 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 61137-48:
(7*6)+(6*1)+(5*1)+(4*3)+(3*7)+(2*4)+(1*8)=102
102 % 10 = 2
So 61137-48-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H18ClN3O3/c1-17-9-4-2-8(3-5-9)12-10(15)14(13-16)7-6-11/h8-9H,2-7H2,1H3,(H,12,15)
61137-48-2Relevant academic research and scientific papers
Synthesis of analogues of N (2 chloroethyl) N' trans 4 methylcyclohexyl) N nitrosourea for evaluation as anticancer agents
Johnston,McCaleb,Clayton,Frye,Krauth,Montgomery
, p. 279 - 290 (2007/10/04)
The superior activity of N (2 chloroethyl) N' (trans 4 methylcyclohexyl) N nitrosourea (MeCCNU) against advanced murine Lewis lung carcinoma in comparisons with the cis form and other nitrosoureas prompted the synthesis of a number of MeCCNU analogues, including several cis trans pairs. The methyl group was replaced by a variety of substituents (CO2H, CH2CO2H, CO2Me, CH2OAc, CH2Cl, OMe); the trans 3 methylcyclohexyl, cis 2 methyl 1,3 dithian 5 yl, cis and trans 2 methyl 1,3 dithian 5 yl tetraoxide, and 1 methylhexyl (open chain) analogues were also prepared. Preliminary tests against murine leukemia L1210 revealed therapeutic indices (ED50/LD10) ranging from 0.26 to 0.79; all but 3 analogues effected 50% cure rates at nontoxic doses, the open chain analogue being one of the least active. In terms of therapeutic index, diequatorial (trans 4) isomers were, with one exception, as active as or, in 4 of the 8 examples, somewhat more active than the corresponding axial equatorial (cis 4) isomers. In this series, 4 of the 5 2-fluoroethyl analogues prepared were clearly inferior to the corresponding 2 chloroethyl analogues.
