61367-28-0

Basic information

• Product Name: 1-(2-chloroethyl)-3-(4-methoxycyclohexyl)urea
• CAS NO: 61367-28-0
• Molecular Formula: C₁₀H₁₉ClN₂O₂
• Molecular Weight: 234.7231
• Mol File: 61367-28-0.mol

Chemical Properties

• Boiling Point: 402.8°C at 760 mmHg
• Flash Point: 197.4°C
• Density: 1.13g/cm³
• Vapor Pressure: 1.07E-06mmHg at 25°C
• Refractive Index: 1.494
• CAS DataBase Reference: 1-(2-chloroethyl)-3-(4-methoxycyclohexyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chloroethyl)-3-(4-methoxycyclohexyl)urea(61367-28-0)
• EPA Substance Registry System: 1-(2-chloroethyl)-3-(4-methoxycyclohexyl)urea(61367-28-0)

Safety Data

• Hazardous Substances Data: 61367-28-0(Hazardous Substances Data)

Usage

Uses

Used in Agricultural Industry:
1-(2-chloroethyl)-3-(4-methoxycyclohexyl)urea is used as a herbicide for controlling the growth of unwanted plants and managing weeds. Its application reason is based on its ability to disrupt the cell division process in plants, thereby inhibiting their growth and allowing for more efficient crop cultivation.
Additionally, it is used as a plant growth regulator to maintain a balanced growth of crops and improve overall yield. 1-(2-chloroethyl)-3-(4-methoxycyclohexyl)urea's regulatory properties help in optimizing plant development, ensuring a more productive and sustainable agricultural practice.
It is crucial to handle 1-(2-chloroethyl)-3-(4-methoxycyclohexyl)urea with care and adhere to the recommended safety guidelines during its application to minimize any potential risks to the environment and human health.

Downstream Products

• 61137-48-2 C₁₀H₁₈ClN₃O₃ 

Relevant articles and documents

Synthesis of analogues of N (2 chloroethyl) N' trans 4 methylcyclohexyl) N nitrosourea for evaluation as anticancer agents

The superior activity of N (2 chloroethyl) N' (trans 4 methylcyclohexyl) N nitrosourea (MeCCNU) against advanced murine Lewis lung carcinoma in comparisons with the cis form and other nitrosoureas prompted the synthesis of a number of MeCCNU analogues, including several cis trans pairs. The methyl group was replaced by a variety of substituents (CO2H, CH2CO2H, CO2Me, CH2OAc, CH2Cl, OMe); the trans 3 methylcyclohexyl, cis 2 methyl 1,3 dithian 5 yl, cis and trans 2 methyl 1,3 dithian 5 yl tetraoxide, and 1 methylhexyl (open chain) analogues were also prepared. Preliminary tests against murine leukemia L1210 revealed therapeutic indices (ED50/LD10) ranging from 0.26 to 0.79; all but 3 analogues effected 50% cure rates at nontoxic doses, the open chain analogue being one of the least active. In terms of therapeutic index, diequatorial (trans 4) isomers were, with one exception, as active as or, in 4 of the 8 examples, somewhat more active than the corresponding axial equatorial (cis 4) isomers. In this series, 4 of the 5 2-fluoroethyl analogues prepared were clearly inferior to the corresponding 2 chloroethyl analogues.