61145-33-3 Usage
Uses
1. Used in Biochemistry and Molecular Biology:
Cyanomethyl 2,3,4,6-tetra-O-acetyl-1-thio-beta-D-galactopyranoside is used as a glycosylating agent for attaching sugar moieties to proteins. The conversion of the nitrile group to a methyl imidate group allows for the formation of stable glycosidic bonds with proteins, which is crucial in various biological processes and applications.
2. Used in Drug Development:
In the pharmaceutical industry, Cyanomethyl 2,3,4,6-tetra-O-acetyl-1-thio-beta-D-galactopyranoside can be utilized in the synthesis of glycoconjugate drugs, which are essential in the treatment of various diseases, including cancer and infectious diseases. The ability to attach sugar moieties to proteins can enhance the efficacy and specificity of these drugs.
3. Used in Chemical Research:
Cyanomethyl 2,3,4,6-tetra-O-acetyl-1-thio-beta-D-galactopyranoside serves as a valuable research tool in organic chemistry and carbohydrate chemistry. Its unique structure and reactivity make it an interesting subject for studying the synthesis and properties of complex carbohydrates and their derivatives.
Check Digit Verification of cas no
The CAS Registry Mumber 61145-33-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,1,4 and 5 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 61145-33:
(7*6)+(6*1)+(5*1)+(4*4)+(3*5)+(2*3)+(1*3)=93
93 % 10 = 3
So 61145-33-3 is a valid CAS Registry Number.
InChI:InChI=1/C16H21NO9S/c1-8(18)22-7-12-13(23-9(2)19)14(24-10(3)20)15(25-11(4)21)16(26-12)27-6-5-17/h12-16H,6-7H2,1-4H3
61145-33-3Relevant academic research and scientific papers
AGENTS FOR CLEARING BIOMOLECULES FROM CIRCULATION
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, (2013/10/22)
Described is a method, and a combination of agents for used therein, by which an agent administered to a subject can be rapidly cleared from circulation. This is achieved by providing an Administration Agent (e.g. a probe for pretargeting) with a reactive group and providing a Clearing Agent with another reactive group, said reactive groups forming a bio-orthogonally reactive pair. Preferably, the reactive pair comprises a cyclooctene or cyclooctyn as one reactant, and a diene as the other reactant. The method and combination can be used for the removal of any bindable molecule from circulation, such as an excess of a pre-targeting probe in the course of a pre-targeting method, a targeting or imaging agent delivered, or the removal of any biomolecule already present in circulation.
Glycoviruses: Chemical glycosylation retargets adenoviral gene transfer
Pearce, Oliver M. T.,Fisher, Kerry D.,Humphries, Julia,Seymour, Leonard W.,Smith, Alberto,Davis, Benjamin G.
, p. 1057 - 1061 (2007/10/03)
A sugar-specific transfection mechanism is introduced by the glycosylation of adenoviruses (AVs, see picture), and manipulation of the glycosylation pattern allows the selective transfection of human macrophages in favor of the usual target. This dramatic retargeting holds promise for the fine-tuning of adenoviruses for applications such as gene therapy.
