61145-67-3Relevant articles and documents
Convenient method for the functionalization of the 4- and 6-positions of the androgen skeleton
Morton, Daniel,Dick, Allison R.,Ghosh, Debashis,Davies, Huw M. L.
supporting information; experimental part, p. 5838 - 5840 (2012/07/14)
The preparation and reactivity of steroidal vinyldiazo compounds is reported, providing a convenient, substituent tolerant, chemo- and stereoselective entry into 4- and 6-substituted androgen analogues from a common precursor. Under dirhodium catalysis, O-H insertion occurs at the carbenoid site, leading to 4-substituted steroids, but under silver catalysis, O-H insertion occurs at the vinylogous position, leading to 6-substituted steroids.
6-Chloro- and 6-bromo-substituted steroids in the Suzuki-Miyaura cross-coupling reaction. A convenient route to potential aromatase inhibitors
Lukashev, Nikolay V.,Latyshev, Gennadij V.,Donez, Pavel A.,Skryabin, George A.,Beletskaya, Irina P.
, p. 533 - 539 (2007/10/03)
Chlorine at an sp2-carbon in steroids has been shown to be reactive in Suzuki-Miyaura cross-coupling reactions with either Ni or Pd catalysts. The coupling of analogous 6-bromo derivatives has also been demonstrated to be applicable to a wider scope of substrates. The Suzuki-Miyaura arylation of 6-bromo-Δ3,5-steroid enol ethers with subsequent hydrolysis is a useful route to 6-arylated steroids bearing aryl at a saturated carbon. Georg Thieme Verlag Stuttgart.
